Furin cleavage of the SARS-CoV-2 spike is modulated by
COVID-19
O-
SARS-CoV-2
furin
glycosylation
spike
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 11 2021
23 11 2021
Historique:
accepted:
29
09
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
12
11
2021
Statut:
ppublish
Résumé
The SARS-CoV-2 coronavirus responsible for the global pandemic contains a novel furin cleavage site in the spike protein (S) that increases viral infectivity and syncytia formation in cells. Here, we show that
Identifiants
pubmed: 34732583
pii: 2109905118
doi: 10.1073/pnas.2109905118
pmc: PMC8617502
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
N-Acetylgalactosaminyltransferases
EC 2.4.1.-
Furin
EC 3.4.21.75
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Intramural NIH HHS
ID : 1 ZIA DE000739
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIC DE000750
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DE000713
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DE000739
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIC DE000750-01
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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