An efficient photochemotherapy nanoplatform based on the endogenous biosynthesis of photosensitizer in macrophage-derived extracellular vesicles.

Doxorubicin Drug Delivery Systems Extracellular Vesicles Macrophages Photochemotherapy Photosensitizing Agents
Biosynthesis Chemotherapy Drug delivery Extracellular vesicles Phototherapy

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
12 2021
Historique:
received: 29 07 2021
revised: 21 10 2021
accepted: 27 10 2021
pubmed: 5 11 2021
medline: 15 12 2021
entrez: 4 11 2021
Statut: ppublish

Résumé

Extracellular vesicles (EVs) have been emerged as versatile drug delivery vehicles due to their outstanding biocompatibility and long-term circulation, yet are constrained with low targeting property and inefficient loading capacity from post-synthetic passive EVs encapsulation. Herein, we report a simple and feasible in situ biosynthetic approach to encapsulate tumor-targeting folate (FA)-modified EVs with intracellularly produced protoporphyrin X (PpIX) and doxorubicin (DOX). As compared with the traditional directly drug-incubated or drug-electroporated EVs, these biosynthesized EVs revealed high drug-loading efficiency with minimized structural and functional perturbations. Our multifunctional EVs revealed the enhanced accumulation and penetration into deep tumor parenchyma, as well as the strengthened immune response to ablate orthotopic and metastatic tumors, thus realizing the more reliable photochemotherapy. As an intelligent multi-mode therapeutic system, our biosynthetic EVs could be engineered with more therapeutic agents and show great promise for biomedicine applications.

Identifiants

DOI: 10.1016/j.biomaterials.2021.121234 PMID: 34736152
pubmed: 34736152
pii: S0142-9612(21)00591-3
doi: 10.1016/j.biomaterials.2021.121234
pii:
doi:

Substances chimiques

Photosensitizing Agents 0
Doxorubicin 80168379AG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

121234

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Ruomeng Li (R)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.

Xue Gong (X)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.

Chen Hong (C)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.

Hong Wang (H)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.

Yingying Chen (Y)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.

Kaiyue Tan (K)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.

Xiaoqing Liu (X)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China; Research Institute of Shenzhen, Wuhan University, Shenzhen, 518057, PR China. Electronic address: xiaoqingliu@whu.edu.cn.

Fuan Wang (F)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China; Research Institute of Shenzhen, Wuhan University, Shenzhen, 518057, PR China. Electronic address: fuanwang@whu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › An efficient photochemotherapy nanoplatform...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › An efficient photochemotherapy nanoplatform...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › An efficient photochemotherapy nanoplatform...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › An efficient photochemotherapy nanoplatform...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › An efficient photochemotherapy nanoplatform...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › An efficient photochemotherapy nanoplatform...