Dopaminergic Activity in Antipsychotic-Naïve Patients Assessed With Positron Emission Tomography Before and After Partial Dopamine D

Antipsychotic Agents / therapeutic use Corpus Striatum Dopamine Dopamine Agonists / therapeutic use Humans Positron-Emission Tomography Psychotic Disorders / diagnostic imaging
Antipsychotic-naïve schizophrenia Aripiprazole Dopa decarboxylase Dopamine F-DOPA Partial agonist Positron emission tomography Psychosis Striatum Treatment outcome dopamine

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
15 01 2022
Historique:
received: 10 03 2021
revised: 30 08 2021
accepted: 30 08 2021
pubmed: 9 11 2021
medline: 29 1 2022
entrez: 8 11 2021
Statut: ppublish

Résumé

Dopamine activity has been associated with the response to antipsychotic treatment. Our study used a four-parameter model to test the association between the striatal decarboxylation rate of Sixty-two individuals (31 patients and 31 control subjects) underwent High baseline decarboxylation rates (k Striatal decarboxylation rate at baseline was associated with psychotic symptoms and treatment response. The strong association between k

Sections du résumé

BACKGROUND
Dopamine activity has been associated with the response to antipsychotic treatment. Our study used a four-parameter model to test the association between the striatal decarboxylation rate of
METHODS
Sixty-two individuals (31 patients and 31 control subjects) underwent
RESULTS
High baseline decarboxylation rates (k
CONCLUSIONS
Striatal decarboxylation rate at baseline was associated with psychotic symptoms and treatment response. The strong association between k

Identifiants

DOI: 10.1016/j.biopsych.2021.08.023 PMID: 34743917
pubmed: 34743917
pii: S0006-3223(21)01568-7
doi: 10.1016/j.biopsych.2021.08.023
pii:
doi:

Substances chimiques

Antipsychotic Agents 0
Dopamine Agonists 0
Dopamine VTD58H1Z2X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

236-245

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

Informations de copyright

Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Anne Korning Sigvard (AK)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: anne.mette.sigvard@regionh.dk.

Mette Ødegaard Nielsen (MØ)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Albert Gjedde (A)

Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Translational Neuropsychiatry Unit, Department of Clinical Medicine, University of Aarhus, Aarhus, Denmark.

Kirsten Borup Bojesen (KB)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Dan Fuglø (D)

Department of Nuclear Medicine, Herlev Hospital, University of Copenhagen, Herlev, Hovedstaden, Denmark.

Karen Tangmose (K)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Yoshitaka Kumakura (Y)

Department of Diagnostic Radiology and Nuclear Medicine, Saitama Medical Center, Saitama Medical University, Saitama, Saitama Prefecture, Japan.

Kim Heltø (K)

Department of Anaesthesiology, Herlev Hospital, University of Copenhagen, Herlev, Hovedstaden, Denmark.

Bjørn H Ebdrup (BH)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Lars Thorbjørn Jensen (LT)

Department of Nuclear Medicine, Herlev Hospital, University of Copenhagen, Herlev, Hovedstaden, Denmark.

Egill Rostrup (E)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Birte Yding Glenthøj (BY)

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Dopaminergic Activity in Antipsychotic-Naïve...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Dopaminergic Activity in Antipsychotic-Naïve...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Dopaminergic Activity in Antipsychotic-Naïve...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents dopaminergiques › Agonistes de la dopamine › Dopaminergic Activity in Antipsychotic-Naïve...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dopaminergic Activity in Antipsychotic-Naïve...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Dopaminergic Activity in Antipsychotic-Naïve...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Dopaminergic Activity in Antipsychotic-Naïve...