Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells.
Adaptor Proteins, Signal Transducing
/ genetics
Agenesis of Corpus Callosum
/ genetics
Animals
Apoptosis Regulatory Proteins
/ genetics
CRISPR-Associated Protein 9
/ genetics
CRISPR-Cas Systems
Cells, Cultured
Databases, Genetic
Gene Knockout Techniques
Gene Regulatory Networks
Hearing Loss, Sensorineural
/ genetics
Hernias, Diaphragmatic, Congenital
/ genetics
Humans
Kidney Tubules, Proximal
/ metabolism
Low Density Lipoprotein Receptor-Related Protein-2
/ genetics
Male
Mice, Knockout
Monodelphis
Myopia
/ genetics
Proteinuria
/ genetics
Receptors, Cell Surface
/ genetics
Renal Tubular Transport, Inborn Errors
/ genetics
Transcription, Genetic
Donnai-Barrow syndrome
endocytosis
renal proximal tubule cell
sodium-glucose cotransporter isoform 2
transcriptional profiling
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
pubmed:
9
11
2021
medline:
15
2
2022
entrez:
8
11
2021
Statut:
ppublish
Résumé
The multiligand receptors megalin (
Identifiants
pubmed: 34747197
doi: 10.1152/ajprenal.00259.2021
pmc: PMC8698540
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Apoptosis Regulatory Proteins
0
DAB2 protein, human
0
Dab2 protein, mouse
0
LRP2 protein, human
0
Low Density Lipoprotein Receptor-Related Protein-2
0
Lrp2 protein, mouse
0
Receptors, Cell Surface
0
intrinsic factor-cobalamin receptor
0
CRISPR-Associated Protein 9
EC 3.1.-
Banques de données
figshare
['10.6084/m9.figshare.14933340.v1']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F14-F26Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK118726
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA082084
Pays : United States
Organisme : HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : R01 AI152104
Organisme : NIDDK NIH HHS
ID : K08 DK118211
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079307
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135027
Pays : United States
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