Host factors: Implications in immunopathogenesis of COVID-19.
ACE2
COVID-19
Genetic susceptibility
Polymorphisms
SARS-CoV-2
Journal
Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
09
05
2021
revised:
03
10
2021
accepted:
04
10
2021
pubmed:
9
11
2021
medline:
15
12
2021
entrez:
8
11
2021
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is more serious in people with underlying diseases, but the cause of healthy people with progressive disease is largely unknown. Host genetic factors such as ACE2 variants, IFITM-3, HLA, TMRSS2, and furin polymorphisms appear to be one of the agents involved in the progression of the COVID-19 and outcome of the disease. This review discusses the general characteristics of SARS-CoV-2, including viral features, receptors, cell entry, clinical findings, and the main human genetic factors that may contribute to the pathogenesis of COVID-19 and get the patients' situation more complex. Further knowledge in this context may help to find a way to prevent and treat this viral pneumonia.
Identifiants
pubmed: 34749207
pii: S0344-0338(21)00308-3
doi: 10.1016/j.prp.2021.153647
pmc: PMC8505027
pii:
doi:
Substances chimiques
HLA Antigens
0
IFITM3 protein, human
0
Membrane Proteins
0
RNA-Binding Proteins
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
FURIN protein, human
EC 3.4.21.75
Furin
EC 3.4.21.75
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
153647Informations de copyright
Copyright © 2021 Elsevier GmbH. All rights reserved.
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