Spatial alanine metabolism determines local growth dynamics of
E. coli
biofilms
colonies
cross-feeding
infectious disease
metabolism
microbiology
phenotypic heterogeneity
physics of living systems
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 11 2021
09 11 2021
Historique:
received:
28
05
2021
accepted:
18
10
2021
entrez:
9
11
2021
pubmed:
10
11
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Bacteria commonly live in spatially structured biofilm assemblages, which are encased by an extracellular matrix. Metabolic activity of the cells inside biofilms causes gradients in local environmental conditions, which leads to the emergence of physiologically differentiated subpopulations. Information about the properties and spatial arrangement of such metabolic subpopulations, as well as their interaction strength and interaction length scales are lacking, even for model systems like
Identifiants
pubmed: 34751128
doi: 10.7554/eLife.70794
pii: 70794
pmc: PMC8579308
doi:
pii:
Substances chimiques
Alanine
OF5P57N2ZX
Banques de données
GEO
['GSE175768']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI103369
Pays : United States
Informations de copyright
© 2021, Díaz-Pascual et al.
Déclaration de conflit d'intérêts
FD, ML, KN, HJ, JJ, KN, RH, EJ, MH, AP, LD, HL, KD No competing interests declared
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