A Three-Component Synthesis of 3-Functionally Substituted 5,6-Dihydropyrrolo[2,1-a]isoquinolines.
CH-acids
domino reaction
pyrrolo[2,1-a]isoquinolines
terminal alkynes
three-component reactions
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
23
07
2021
accepted:
08
11
2021
pubmed:
10
11
2021
medline:
4
2
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active.
Identifiants
pubmed: 34752012
doi: 10.1002/cbdv.202100584
doi:
Substances chimiques
Alkynes
0
Isoquinolines
0
Pyrroles
0
pyrrolo(2,1-a)isoquinoline
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100584Subventions
Organisme : Russian Science Foundation
ID : 18-73-10099
Organisme : RUDN University Strategic Academic Leadership Program.
Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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