Condensed Supramolecular Helices: The Twisted Sisters of DNA.
DNA-like helix superstructures
chirality
condensation
hexagonally packed helices
polyelectrolyte-bile salt systems
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
21 01 2022
21 01 2022
Historique:
received:
30
09
2021
pubmed:
11
11
2021
medline:
22
2
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
Condensation of DNA helices into hexagonally packed bundles and toroids represents an intriguing example of functional organization of biological macromolecules at the nanoscale. The condensation models are based on the unique polyelectrolyte features of DNA, however here we could reproduce a DNA-like condensation with supramolecular helices of small chiral molecules, thereby demonstrating that it is a more general phenomenon. We show that the bile salt sodium deoxycholate can form supramolecular helices upon interaction with oppositely charged polyelectrolytes of homopolymer or block copolymers. At higher order, a controlled hexagonal packing of the helices into DNA-like bundles and toroids could be accomplished. The results disclose unknown similarities between covalent and supramolecular non-covalent helical polyelectrolytes, which inspire visionary ideas of constructing supramolecular versions of biological macromolecules. As drug nanocarriers the polymer-bile salt superstructures would get advantage of a complex chirality at molecular and supramolecular levels, whose effect on the nanocarrier assisted drug efficiency is a still unexplored fascinating issue.
Identifiants
pubmed: 34757695
doi: 10.1002/anie.202113279
pmc: PMC9300030
doi:
Substances chimiques
Macromolecular Substances
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202113279Subventions
Organisme : Crafoordska Stiftelsen
ID : 20180549
Organisme : Crafoordska Stiftelsen
ID : 20170927
Organisme : Swedish Foundation for International Cooperation in Research and Higher Education
ID : CH2017-7159
Organisme : Magnus Bergvalls Stiftelse
ID : 2017-02225
Organisme : Vetenskapsrådet
ID : 2015-05042
Organisme : Sapienza Università di Roma
ID : RM11816428917C3F
Organisme : National Natural Science Foundation of China
ID : 21811530002
Organisme : China Scholarship Council
ID : 201706870015
Informations de copyright
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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