POGZ promotes homology-directed DNA repair in an HP1-dependent manner.
DNA double-strand break
HP1
POGZ
homologous recombination
white Sutton syndrome
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 01 2022
05 01 2022
Historique:
revised:
08
10
2021
received:
05
06
2020
accepted:
20
10
2021
pubmed:
11
11
2021
medline:
15
3
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that the zinc finger protein POGZ promotes the presence of HP1 at DNA double-strand breaks (DSBs) in human cells. POGZ depletion delays the resolution of DSBs and sensitizes cells to different DNA-damaging agents, including cisplatin and talazoparib. Mechanistically, POGZ promotes homology-directed DNA repair by retaining the BRCA1/BARD1 complex at DSBs in an HP1-dependent manner. In vivo CRISPR inactivation of Pogz is embryonically lethal. Pogz haploinsufficiency (Pogz
Identifiants
pubmed: 34758190
doi: 10.15252/embr.202051041
pmc: PMC8728601
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
POGZ protein, human
0
Chromobox Protein Homolog 5
107283-02-3
DNA
9007-49-2
Transposases
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e51041Subventions
Organisme : CIHR
ID : 376245
Pays : Canada
Organisme : CIHR
ID : 159759
Pays : Canada
Organisme : CIHR
ID : 376288
Pays : Canada
Informations de copyright
© 2021 The Authors.
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