Why Levosimendan Improves the Clinical Condition of Patients With Advanced Heart Failure: A Holistic Approach.


Journal

Journal of cardiac failure
ISSN: 1532-8414
Titre abrégé: J Card Fail
Pays: United States
ID NLM: 9442138

Informations de publication

Date de publication:
03 2022
Historique:
received: 04 08 2021
revised: 21 09 2021
accepted: 12 10 2021
pubmed: 12 11 2021
medline: 4 5 2022
entrez: 11 11 2021
Statut: ppublish

Résumé

In advanced heart failure (HF), levosimendan increases peak oxygen uptake (VO Twenty patients hospitalized for advanced HF underwent, before and shortly after levosimendan infusion, 2 different cardiopulmonary exercise tests: (a) a personalized ramp protocol with repeated arterial blood gas analysis and standard spirometry including alveolar-capillary gas diffusion measurements at rest and at peak exercise, and (b) a step incremental workload cardiopulmonary exercise testing with continuous near-infrared spectroscopy analysis and cardiac output assessment by bioelectrical impedance analysis.Levosimendan significantly decreased natriuretic peptides, improved peak VO In advanced HF, levosimendan increases peak VO

Sections du résumé

BACKGROUND
In advanced heart failure (HF), levosimendan increases peak oxygen uptake (VO
METHODS AND RESULTS
Twenty patients hospitalized for advanced HF underwent, before and shortly after levosimendan infusion, 2 different cardiopulmonary exercise tests: (a) a personalized ramp protocol with repeated arterial blood gas analysis and standard spirometry including alveolar-capillary gas diffusion measurements at rest and at peak exercise, and (b) a step incremental workload cardiopulmonary exercise testing with continuous near-infrared spectroscopy analysis and cardiac output assessment by bioelectrical impedance analysis.Levosimendan significantly decreased natriuretic peptides, improved peak VO
CONCLUSIONS
In advanced HF, levosimendan increases peak VO

Identifiants

pubmed: 34763079
pii: S1071-9164(21)00435-8
doi: 10.1016/j.cardfail.2021.10.009
pii:
doi:

Substances chimiques

Hemoglobins 0
Simendan 349552KRHK
Oxygen S88TT14065

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

509-514

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest None declared.

Auteurs

Anna Apostolo (A)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Carlo Vignati (C)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Michele Della Rocca (M)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Fabiana De Martino (F)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Giovanni Berna (G)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Jeness Campodonico (J)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Mauro Contini (M)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Manuela Muratori (M)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Pietro Palermo (P)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Massimo Mapelli (M)

Centro Cardiologico Monzino, IRCCS, Milan, Italy; Cardiovascular Section, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Marina Alimento (M)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Beatrice Pezzuto (B)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Piergiuseppe Agostoni (P)

Centro Cardiologico Monzino, IRCCS, Milan, Italy; Cardiovascular Section, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address: piergiuseppe.agostoni@ccfm.it.

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Classifications MeSH