A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B
A. baumannii
PKPD model
inoculum effect
polymyxin B
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
18 01 2022
18 01 2022
Historique:
pubmed:
16
11
2021
medline:
23
3
2022
entrez:
15
11
2021
Statut:
ppublish
Résumé
The inoculum effect (i.e., reduction in antimicrobial activity at large starting inoculum) is a phenomenon described for various pathogens. Given that limited data exist regarding inoculum effect of Acinetobacter baumannii, we evaluated killing of A. baumannii by polymyxin B, a last-resort antibiotic, at several starting inocula and developed a pharmacokinetic-pharmacodynamic (PKPD) model to capture this phenomenon.
Identifiants
pubmed: 34780268
doi: 10.1128/AAC.01789-21
pmc: PMC8765416
doi:
Substances chimiques
Anti-Bacterial Agents
0
Polymyxin B
J2VZ07J96K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0178921Références
mBio. 2019 Jul 16;10(4):
pubmed: 31311879
PLoS One. 2019 Jan 23;14(1):e0211214
pubmed: 30673774
Infect Immun. 2004 Dec;72(12):7107-14
pubmed: 15557634
J Infect Dis. 2013 Oct 1;208(7):1142-51
pubmed: 23812239
J Clin Microbiol. 2019 Feb 27;57(3):
pubmed: 30567745
Antimicrob Agents Chemother. 2010 May;54(5):2051-62
pubmed: 20211900
J Pharmacokinet Pharmacodyn. 2001 Oct;28(5):481-504
pubmed: 11768292
Antibiotics (Basel). 2020 Dec 15;9(12):
pubmed: 33334045
Clin Microbiol Infect. 2010 Feb;16(2):132-6
pubmed: 19614715
FEMS Microbiol Lett. 2020 Mar 1;367(5):
pubmed: 31960902
J Infect Dis. 2011 Oct 1;204(7):1147-8
pubmed: 21881133
J Antimicrob Chemother. 2014 May;69(5):1350-61
pubmed: 24474432
Antimicrob Agents Chemother. 2010 Nov;54(11):4739-43
pubmed: 20805390
CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):87-109
pubmed: 27884052
Int J Antimicrob Agents. 2018 Jun;51(6):888-896
pubmed: 29432867
Clin Microbiol Infect. 2014 Nov;20(11):O831-9
pubmed: 24813594
J Antimicrob Chemother. 2009 Apr;63(4):745-57
pubmed: 19218572
J Antimicrob Chemother. 2017 Nov 1;72(11):3108-3116
pubmed: 28961946
PLoS Comput Biol. 2016 Mar 11;12(3):e1004782
pubmed: 26967893
Clin Microbiol Rev. 2015 Jan;28(1):191-207
pubmed: 25567227
Clin Infect Dis. 2008 Nov 15;47(10):1298-304
pubmed: 18840079
Antimicrob Agents Chemother. 2010 Dec;54(12):4971-7
pubmed: 20855724
Antimicrob Agents Chemother. 2009 Jan;53(1):46-56
pubmed: 18852268
J Antimicrob Chemother. 2005 Jul;56(1):91-6
pubmed: 15890721
J Pharm Biomed Anal. 2002 Jun 20;29(1-2):203-12
pubmed: 12062679
Antimicrob Agents Chemother. 2011 Jul;55(7):3370-9
pubmed: 21576434
Clin Microbiol Rev. 2017 Jan;30(1):409-447
pubmed: 27974412
Curr Opin Infect Dis. 2019 Feb;32(1):69-76
pubmed: 30520737
Pharmacol Rev. 2013 Jun 26;65(3):1053-90
pubmed: 23803529
Crit Care. 2014 Mar 18;18(2):208
pubmed: 25029020
J Antimicrob Chemother. 2019 Oct 1;74(10):2825-2843
pubmed: 31170287
Antimicrob Agents Chemother. 2007 Jan;51(1):128-36
pubmed: 17060524
Antimicrob Agents Chemother. 2015 Aug;59(8):5014-7
pubmed: 25987630
Antimicrob Agents Chemother. 2009 Nov;53(11):4740-8
pubmed: 19738020
Antimicrob Agents Chemother. 2001 Dec;45(12):3548-54
pubmed: 11709338
Antimicrob Agents Chemother. 2011 Apr;55(4):1571-9
pubmed: 21282424
Antimicrob Agents Chemother. 2005 Sep;49(9):3624-30
pubmed: 16127031
Rev Infect Dis. 1989 May-Jun;11(3):361-8
pubmed: 2664999