Peptide-YY
Animals
Blood Glucose
/ metabolism
Body Weight
/ drug effects
Diabetes Mellitus, Experimental
/ metabolism
Diabetes Mellitus, Type 2
/ metabolism
Diet
Eating
/ drug effects
Energy Intake
/ drug effects
Energy Metabolism
/ drug effects
Gastric Bypass
Glucagon-Like Peptide 1
/ metabolism
Glucagon-Like Peptide-1 Receptor
/ metabolism
Hypothalamus
Insulin Resistance
/ physiology
Insulin-Secreting Cells
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
/ metabolism
Peptide YY
/ metabolism
Weight Loss
Central nervous system
Diabetes
Diabetes remission
Glucagon-like peptide-1 (GLP-1)
Glucose homeostasis
Hypothalamus
Insulin sensitivity
Obesity
Pancreatic β-cell
Peptide-YY(3-36) (PYY(3-36))
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
22
07
2021
revised:
22
10
2021
accepted:
04
11
2021
pubmed:
16
11
2021
medline:
29
3
2022
entrez:
15
11
2021
Statut:
ppublish
Résumé
Obesity-linked type 2 diabetes (T2D) is a worldwide health concern and many novel approaches are being considered for its treatment and subsequent prevention of serious comorbidities. Co-administration of glucagon like peptide 1 (GLP-1) and peptide YY In this study, we utilized long-acting analogues of GLP-1 and PYY Co-administration of long-acting Fc-IgG/peptide conjugates of Fc-GLP-1 and Fc-PYY These results reveal a therapeutic approach for obesity/T2D that improved insulin sensitivity and restored endogenous β-cell function. These data also highlight the potential association between the gut-brain axis in control of metabolic homeostasis.
Identifiants
pubmed: 34781035
pii: S2212-8778(21)00247-7
doi: 10.1016/j.molmet.2021.101392
pmc: PMC8717237
pii:
doi:
Substances chimiques
Blood Glucose
0
Glucagon-Like Peptide-1 Receptor
0
Peptide YY
106388-42-5
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101392Subventions
Organisme : NIDDK NIH HHS
ID : U24 DK059637
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.