Engineered microbial consortia: strategies and applications.
Journal
Microbial cell factories
ISSN: 1475-2859
Titre abrégé: Microb Cell Fact
Pays: England
ID NLM: 101139812
Informations de publication
Date de publication:
16 Nov 2021
16 Nov 2021
Historique:
received:
24
08
2021
accepted:
23
10
2021
entrez:
17
11
2021
pubmed:
18
11
2021
medline:
1
2
2022
Statut:
epublish
Résumé
Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these limitations, microbial consortia can be engineered to distribute complex tasks among multiple populations. Recent studies have made substantial progress in programming microbial consortia for both basic understanding and potential applications. Microbial consortia have been designed through diverse strategies, including programming mutualistic interactions, using programmed population control to prevent overgrowth of individual populations, and spatial segregation to reduce competition. Here, we highlight the role of microbial consortia in the advances of metabolic engineering, biofilm production for engineered living materials, biocomputing, and biosensing. Additionally, we discuss the challenges for future research in microbial consortia.
Identifiants
pubmed: 34784924
doi: 10.1186/s12934-021-01699-9
pii: 10.1186/s12934-021-01699-9
pmc: PMC8597270
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
211Informations de copyright
© 2021. The Author(s).
Références
Metab Eng. 2019 Sep;55:268-275
pubmed: 31401244
Nat Commun. 2019 Nov 29;10(1):5469
pubmed: 31784537
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4838-43
pubmed: 24639514
Metab Eng. 2019 Jul;54:1-11
pubmed: 30844431
Front Bioeng Biotechnol. 2019 Mar 11;7:40
pubmed: 30915329
Nat Chem Biol. 2019 Jun;15(6):589-597
pubmed: 31086330
Biofilm. 2021 Sep 20;3:100057
pubmed: 34729468
Nat Chem Biol. 2021 Jun;17(6):732-738
pubmed: 33737758
PLoS Comput Biol. 2016 Feb 01;12(2):e1004685
pubmed: 26829588
Biotechnol J. 2016 Jul;11(7):981-7
pubmed: 27168529
ACS Synth Biol. 2018 May 18;7(5):1436-1446
pubmed: 29638114
ACS Synth Biol. 2019 Sep 20;8(9):2051-2058
pubmed: 31361464
Science. 1991 Jun 21;252(5013):1675-81
pubmed: 1904627
Metab Eng. 2019 Mar;52:224-231
pubmed: 30553933
Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2149-56
pubmed: 24778240
Nat Chem. 2015 Aug;7(8):673-8
pubmed: 26201745
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8266-71
pubmed: 26111796
ACS Synth Biol. 2020 Sep 18;9(9):2588-2599
pubmed: 32786361
Nat Rev Microbiol. 2012 Jul 16;10(8):538-50
pubmed: 22796884
Nat Commun. 2016 Aug 02;7:12285
pubmed: 27481625
Annu Rev Microbiol. 2006;60:131-47
pubmed: 16704339
Nat Commun. 2021 Feb 8;12(1):853
pubmed: 33558556
Sci Adv. 2018 Dec 07;4(12):eaau1459
pubmed: 30539145
Chem Biol. 2014 Dec 18;21(12):1629-38
pubmed: 25455858
Int J Mol Sci. 2013 Jul 30;14(8):15838-59
pubmed: 23903045
Nat Chem Biol. 2019 Feb;15(2):196-204
pubmed: 30478458
Science. 2015 Nov 6;350(6261):663-6
pubmed: 26542567
Cell. 2019 Apr 18;177(3):782-796.e27
pubmed: 30955892
Nat Chem Biol. 2021 Jun;17(6):724-731
pubmed: 33820990
ACS Synth Biol. 2015 Jan 16;4(1):8-11
pubmed: 25592034
Metab Eng. 2021 Mar;64:146-153
pubmed: 33571657
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2388-93
pubmed: 26858408
Nat Commun. 2020 Mar 4;11(1):1193
pubmed: 32132536
Cell. 2009 Jun 26;137(7):1272-81
pubmed: 19563759
Mol Syst Biol. 2007;3:133
pubmed: 17700541
Mol Syst Biol. 2016 Feb 29;12(2):859
pubmed: 26925805
Cell. 2018 Jul 26;174(3):649-658.e16
pubmed: 30033369
Nat Biotechnol. 2015 Apr;33(4):377-83
pubmed: 25558867
Biosens Bioelectron. 2013 Feb 15;40(1):368-76
pubmed: 22981411
Nature. 2005 Nov 24;438(7067):441-2
pubmed: 16306980
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17300-4
pubmed: 17959781
Nat Microbiol. 2017 Jun 12;2:17083
pubmed: 28604679
Soft Matter. 2011;7(7):3307-3314
pubmed: 21760831
Science. 2018 May 25;360(6391):915-918
pubmed: 29798884
Nat Commun. 2020 Feb 4;11(1):563
pubmed: 32019917
Nature. 2000 Jan 20;403(6767):335-8
pubmed: 10659856
Nat Chem Biol. 2011 May 22;7(7):445-52
pubmed: 21602812
Nat Commun. 2020 May 15;11(1):2418
pubmed: 32415107
Nature. 2010 Jan 28;463(7280):559-62
pubmed: 20111002
Nat Ecol Evol. 2017 Mar 27;1(5):109
pubmed: 28812687
Science. 2019 Sep 6;365(6457):1045-1049
pubmed: 31488693
Nat Commun. 2019 Sep 6;10(1):4028
pubmed: 31492904
Mol Syst Biol. 2017 Apr 3;13(4):923
pubmed: 28373240
ACS Synth Biol. 2020 Mar 20;9(3):590-597
pubmed: 32040906
Nat Commun. 2019 Jan 16;10(1):242
pubmed: 30651549
Nat Biotechnol. 2012 Mar 25;30(4):354-9
pubmed: 22446695
ACS Synth Biol. 2016 Sep 16;5(9):969-77
pubmed: 27172092
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18188-93
pubmed: 19011107
Mol Syst Biol. 2018 Jun 21;14(6):e8157
pubmed: 29930200
J Intern Med. 2012 Dec;272(6):541-61
pubmed: 23025745
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2526-2531
pubmed: 29463749
Mol Syst Biol. 2008;4:187
pubmed: 18414488
Nat Chem Biol. 2019 Jul;15(7):690-698
pubmed: 31110305
Nature. 2004 Apr 22;428(6985):868-71
pubmed: 15064770
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6236-41
pubmed: 27194723
Biotechnol Adv. 1995;13(2):247-61
pubmed: 14537822
Nat Biotechnol. 2017 Jul;35(7):653-658
pubmed: 28553941
ACS Synth Biol. 2019 Feb 15;8(2):434-444
pubmed: 30608638
Adv Mater. 2018 May;30(19):e1704847
pubmed: 29430725
Nature. 2011 Jan 13;469(7329):212-5
pubmed: 21150903
Nat Chem Biol. 2019 Nov;15(11):1102-1109
pubmed: 31611703
Biotechnol Bioeng. 2017 Sep;114(9):1937-1945
pubmed: 28464256
Curr Biol. 2018 Jun 18;28(12):1903-1913.e5
pubmed: 29887307
ACS Synth Biol. 2019 Jan 18;8(1):119-126
pubmed: 30540439
Science. 2015 Aug 28;349(6251):986-9
pubmed: 26315440
Trends Biotechnol. 2019 Feb;37(2):181-197
pubmed: 30497870
Nat Chem Biol. 2009 Nov;5(11):842-8
pubmed: 19801994
Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7214-7219
pubmed: 30923122
Science. 2014 Nov 14;346(6211):1256272
pubmed: 25395541
Nature. 2000 Jan 20;403(6767):339-42
pubmed: 10659857
Nat Chem Biol. 2019 Oct;15(10):1017-1024
pubmed: 31527836
Nat Commun. 2021 Mar 8;12(1):1498
pubmed: 33686084
Nature. 2011 Jan 13;469(7329):207-11
pubmed: 21150900
Nat Commun. 2020 Aug 24;11(1):4226
pubmed: 32839450
Nat Chem Biol. 2018 Aug;14(8):821-829
pubmed: 29942078
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1877-82
pubmed: 17267602
Anal Chem. 2018 Sep 4;90(17):10577-10584
pubmed: 30060656
Science. 1991 Jun 21;252(5013):1668-75
pubmed: 2047876
ACS Synth Biol. 2016 Nov 18;5(11):1290-1298
pubmed: 27346389
Cell Rep. 2020 Mar 3;30(9):3139-3148.e4
pubmed: 32130913
Bioconjug Chem. 2021 Sep 15;32(9):2032-2042
pubmed: 34469136
Nat Chem Biol. 2018 Jan;14(1):29-35
pubmed: 29131146
PLoS One. 2011 Feb 09;6(2):e16791
pubmed: 21347422
Science. 2020 Aug 28;369(6507):
pubmed: 32855308
BMC Syst Biol. 2015 Sep 16;9:59
pubmed: 26377684
ACS Synth Biol. 2019 Aug 16;8(8):1713-1722
pubmed: 31382741
Nature. 2013 Apr 25;496(7446):528-32
pubmed: 23575629
Nature. 2011 Jan 13;469(7329):171-2
pubmed: 21228867
Nat Rev Microbiol. 2013 Mar;11(3):157-68
pubmed: 23353768
Nat Commun. 2020 Jul 21;11(1):3659
pubmed: 32694598