DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions.


Journal

Physics in medicine and biology
ISSN: 1361-6560
Titre abrégé: Phys Med Biol
Pays: England
ID NLM: 0401220

Informations de publication

Date de publication:
15 12 2021
Historique:
received: 03 09 2021
accepted: 16 11 2021
pubmed: 18 11 2021
medline: 4 5 2022
entrez: 17 11 2021
Statut: epublish

Résumé

The chemical stage of the Monte Carlo track-structure (MCTS) code Geant4-DNA was extended for its use in DNA strand break (SB) simulations and compared against published experimental data. Geant4-DNA simulations were performed using pUC19 plasmids (2686 base pairs) in a buffered solution of DMSO irradiated by

Identifiants

pubmed: 34787099
doi: 10.1088/1361-6560/ac3a22
pmc: PMC9765991
mid: NIHMS1853704
doi:

Substances chimiques

DNA 9007-49-2
Dimethyl Sulfoxide YOW8V9698H

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01 CA187003
Pays : United States

Informations de copyright

© 2021 Institute of Physics and Engineering in Medicine.

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Auteurs

N D-Kondo (N)

Faculty of Mathematics and Physics Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

E Moreno-Barbosa (E)

Faculty of Mathematics and Physics Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

V Štěphán (V)

Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, Prague, Czech Republic.

K Stefanová (K)

Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, Prague, Czech Republic.

Y Perrot (Y)

Laboratoire de Dosimétrie des Rayonnements Ionisants, Institut de Radioprotection et Sûreté Nucléaire, Fontenay aux Roses, BP. 17, F-92262, France.

C Villagrasa (C)

Laboratoire de Dosimétrie des Rayonnements Ionisants, Institut de Radioprotection et Sûreté Nucléaire, Fontenay aux Roses, BP. 17, F-92262, France.

S Incerti (S)

Univ. Bordeaux, CNRS/IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France.

B De Celis Alonso (B)

Faculty of Mathematics and Physics Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

J Schuemann (J)

Department of Radiation Oncology, Massachusets General Hospital and Hardvard Medical School, Boston, MA, United States of America.

B Faddegon (B)

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States of America.

J Ramos-Méndez (J)

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States of America.

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Classifications MeSH