Type IV Pili: dynamic bacterial nanomachines.
bacteria
bacterial appendages
bacterial behaviors
dynamics
nanomachines
type IV pili
Journal
FEMS microbiology reviews
ISSN: 1574-6976
Titre abrégé: FEMS Microbiol Rev
Pays: England
ID NLM: 8902526
Informations de publication
Date de publication:
03 03 2022
03 03 2022
Historique:
received:
19
07
2021
accepted:
08
11
2021
pubmed:
18
11
2021
medline:
6
5
2022
entrez:
17
11
2021
Statut:
ppublish
Résumé
Bacteria and archaea rely on appendages called type IV pili (T4P) to participate in diverse behaviors including surface sensing, biofilm formation, virulence, protein secretion and motility across surfaces. T4P are broadly distributed fibers that dynamically extend and retract, and this dynamic activity is essential for their function in broad processes. Despite the essentiality of dynamics in T4P function, little is known about the role of these dynamics and molecular mechanisms controlling them. Recent advances in microscopy have yielded insight into the role of T4P dynamics in their diverse functions and recent structural work has expanded what is known about the inner workings of the T4P motor. This review discusses recent progress in understanding the function, regulation, and mechanisms of T4P dynamics.
Identifiants
pubmed: 34788436
pii: 6425739
doi: 10.1093/femsre/fuab053
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Fimbriae Proteins
147680-16-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.