Motor-independent retraction of type IV pili is governed by an inherent property of the pilus filament.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 11 2021
Historique:
accepted: 05 10 2021
entrez: 18 11 2021
pubmed: 19 11 2021
medline: 22 12 2021
Statut: ppublish

Résumé

Type IV pili (T4P) are dynamic surface appendages that promote virulence, biofilm formation, horizontal gene transfer, and motility in diverse bacterial species. Pilus dynamic activity is best characterized in T4P that use distinct ATPase motors for pilus extension and retraction. Many T4P systems, however, lack a dedicated retraction motor, and the mechanism underlying this motor-independent retraction remains a mystery. Using the

Identifiants

pubmed: 34789573
pii: 2102780118
doi: 10.1073/pnas.2102780118
pmc: PMC8617508
pii:
doi:

Substances chimiques

Type II Secretion Systems 0
Fimbriae Proteins 147680-16-8
Adenosine Triphosphatases EC 3.6.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM128674
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Jennifer L Chlebek (JL)

Department of Biology, Indiana University, Bloomington, IN 47405.

Rémi Denise (R)

Microbial Evolutionary Genomics, CNRS UMR3525, Institut Pasteur, 75015 Paris, France.

Lisa Craig (L)

Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby BC V5A 1S6, Canada.

Ankur B Dalia (AB)

Department of Biology, Indiana University, Bloomington, IN 47405; ankdalia@indiana.edu.

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Classifications MeSH