Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions.


Journal

Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777

Informations de publication

Date de publication:
12 2021
Historique:
received: 22 08 2021
accepted: 19 09 2021
pubmed: 19 11 2021
medline: 24 3 2022
entrez: 18 11 2021
Statut: ppublish

Résumé

Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a small fraction of leukaemic cells that elude treatment and survive in specialised, oxygen (O

Identifiants

pubmed: 34791807
doi: 10.1111/jcmm.17027
pmc: PMC8650039
doi:

Substances chimiques

Antigens, Neoplasm 0
Antineoplastic Agents 0
Carbonic Anhydrase Inhibitors 0
FLT3 protein, human EC 2.7.10.1
fms-Like Tyrosine Kinase 3 EC 2.7.10.1
CA9 protein, human EC 4.2.1.1
Carbonic Anhydrase IX EC 4.2.1.1
Carbonic Anhydrases EC 4.2.1.1
carbonic anhydrase XII EC 4.2.1.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11039-11052

Informations de copyright

© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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Auteurs

Fangli Chen (F)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

Emilia Licarete (E)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.
Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania.

Xue Wu (X)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

Daniela Petrusca (D)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

Callista Maguire (C)

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.

Max Jacobsen (M)

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.

Austyn Colter (A)

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.

George E Sandusky (GE)

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.

Magdalena Czader (M)

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.

Maegan L Capitano (ML)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

James P Ropa (JP)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

H Scott Boswell (HS)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

Fabrizio Carta (F)

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze, Italy.

Claudiu T Supuran (CT)

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Firenze, Italy.

Brian Parkin (B)

Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Melissa L Fishel (ML)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.
Department of Pediatrics, Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA.
Department of Pharmacology & Toxicology, Indiana University, Indianapolis, Indiana, USA.

Heiko Konig (H)

Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.

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Classifications MeSH