Sweet sensation: Developing a single-cell fluorescent reporter of glycolytic heterogeneity.


Journal

Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030

Informations de publication

Date de publication:
18 11 2021
Historique:
entrez: 19 11 2021
pubmed: 20 11 2021
medline: 6 1 2022
Statut: ppublish

Résumé

Conversion of in vitro selected aptamers into functional metabolic sensors is hampered by reduced in vivo aptamer binding and limited tunability of cellular metabolite levels. In this issue of Cell Chemical Biology, Ortega et al. (2021) construct RNA sensors of fructose-6-bisphosphate (FBP) that report on metabolite levels within single yeast cells.

Identifiants

pubmed: 34798034
pii: S2451-9456(21)00477-3
doi: 10.1016/j.chembiol.2021.10.013
pii:
doi:

Substances chimiques

Coloring Agents 0
Fructosediphosphates 0
RNA 63231-63-0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1539-1541

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Diane B Karloff (DB)

Department of Chemistry, Emory University, Atlanta, GA 30322, USA.

Jennifer M Heemstra (JM)

Department of Chemistry, Emory University, Atlanta, GA 30322, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA. Electronic address: jen.heemstra@emory.edu.

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Classifications MeSH