The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study.
Blood culture contaminations
Bloodstream infections
COVID-19
ICU
Surveillance
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
22 11 2021
22 11 2021
Historique:
received:
01
10
2021
accepted:
04
11
2021
entrez:
23
11
2021
pubmed:
24
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cultures drawn in ICUs during the first two pandemic waves of COVID-19 in Switzerland. We analyzed data on positive blood cultures among ICU patients, prospectively collected through a nationwide surveillance system (ANRESIS), from March 30, 2020, to May 31, 2021, a 14-month timeframe that included a first wave of COVID-19, which affected the French and Italian-speaking regions, an interim period (summer 2020) and a second wave that affected the entire country. We used the number of ICU patient-days provided by the Swiss Federal Office of Public Health as denominator to calculate incidence rates of blood culture contaminations and bloodstream infections (ICU-BSI). Incidence rate ratios comparing the interim period with the second wave were determined by segmented Poisson regression models. A total of 1099 blood culture contaminations and 1616 ICU-BSIs were identified in 52 ICUs during the study. Overall, more episodes of blood culture contaminations and ICU-BSI were observed during the pandemic waves, compared to the interim period. The proportions of blood culture contaminations and ICU-BSI were positively associated with the ICU occupancy rate, which was higher during the COVID-19 waves. During the more representative second wave (versus interim period), we observed an increased incidence of blood culture contaminations (IRR 1.57, 95% CI 1.16-2.12) and ICU-BSI (IRR 1.20, 95% CI 1.03-1.39). An increase in blood culture contaminations and ICU-BSIs was observed during the second COVID-19 pandemic wave, especially in months when the ICU burden of COVID-19 patients was high.
Sections du résumé
BACKGROUND
Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cultures drawn in ICUs during the first two pandemic waves of COVID-19 in Switzerland.
METHODS
We analyzed data on positive blood cultures among ICU patients, prospectively collected through a nationwide surveillance system (ANRESIS), from March 30, 2020, to May 31, 2021, a 14-month timeframe that included a first wave of COVID-19, which affected the French and Italian-speaking regions, an interim period (summer 2020) and a second wave that affected the entire country. We used the number of ICU patient-days provided by the Swiss Federal Office of Public Health as denominator to calculate incidence rates of blood culture contaminations and bloodstream infections (ICU-BSI). Incidence rate ratios comparing the interim period with the second wave were determined by segmented Poisson regression models.
RESULTS
A total of 1099 blood culture contaminations and 1616 ICU-BSIs were identified in 52 ICUs during the study. Overall, more episodes of blood culture contaminations and ICU-BSI were observed during the pandemic waves, compared to the interim period. The proportions of blood culture contaminations and ICU-BSI were positively associated with the ICU occupancy rate, which was higher during the COVID-19 waves. During the more representative second wave (versus interim period), we observed an increased incidence of blood culture contaminations (IRR 1.57, 95% CI 1.16-2.12) and ICU-BSI (IRR 1.20, 95% CI 1.03-1.39).
CONCLUSIONS
An increase in blood culture contaminations and ICU-BSIs was observed during the second COVID-19 pandemic wave, especially in months when the ICU burden of COVID-19 patients was high.
Identifiants
pubmed: 34809698
doi: 10.1186/s13054-021-03814-z
pii: 10.1186/s13054-021-03814-z
pmc: PMC8607066
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
403Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : P4P4PM_194449
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 179500
Organisme : 7th Framework Programme (FP7/2007-2013
ID : 115523
Organisme : 7th Framework Programme (FP7/2007-2013
ID : 115620
Organisme : 7th Framework Programme (FP7/2007-2013
ID : 115737
Informations de copyright
© 2021. The Author(s).
Références
Eur J Clin Invest. 2020 Oct;50(10):e13319
pubmed: 32535894
BMC Infect Dis. 2021 Jun 11;21(1):556
pubmed: 34116643
BMJ. 2007 Oct 20;335(7624):806-8
pubmed: 17947786
Clin Infect Dis. 2021 Jun 18;:
pubmed: 34145450
Emerg Infect Dis. 2021 Nov;27(10):2588-2594
pubmed: 34352195
Clin Microbiol Infect. 2020 Oct;26(10):1395-1399
pubmed: 32603803
Clin Microbiol Rev. 2019 Oct 30;33(1):
pubmed: 31666280
BMC Infect Dis. 2021 Feb 22;21(1):199
pubmed: 33618663
Infect Control Hosp Epidemiol. 2021 Feb 19;:1-6
pubmed: 33602361
Expert Rev Anti Infect Ther. 2013 Dec;11(12):1281-90
pubmed: 24188131
Intensive Care Med. 2021 Feb;47(2):180-187
pubmed: 33506379
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Feb 11;:
pubmed: 33663873
Infect Control Hosp Epidemiol. 2021 Jun 24;:1-3
pubmed: 34247662
Infect Control Hosp Epidemiol. 2021 Apr 26;:1-7
pubmed: 33896442
PLoS One. 2020 Nov 23;15(11):e0242533
pubmed: 33226995
J Clin Microbiol. 2020 Jul 23;58(8):
pubmed: 32404482
Clin Microbiol Infect. 2021 Jun 7;:
pubmed: 34111586