Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin- and mucosa-resident memory T cells.
Adult
Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes
/ immunology
Female
HIV Infections
/ drug therapy
HIV Long-Term Survivors
HIV-1
/ physiology
Humans
Immunologic Deficiency Syndromes
/ drug therapy
Male
Memory T Cells
/ immunology
Middle Aged
Mucous Membrane
/ immunology
Receptors, CXCR3
/ metabolism
Sequence Analysis, RNA
Single-Cell Analysis
Skin
/ immunology
Time-to-Treatment
Young Adult
CXCR3
HIV
HPV
cancer
mucosal immunity
skin
tissue-resident memory T cells
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
14 12 2021
14 12 2021
Historique:
received:
11
03
2021
revised:
20
07
2021
accepted:
27
10
2021
pubmed:
24
11
2021
medline:
19
2
2022
entrez:
23
11
2021
Statut:
ppublish
Résumé
People living with HIV (PLWH) are at increased risk for developing skin and mucosal malignancies despite systemic reconstitution of CD4
Identifiants
pubmed: 34813775
pii: S1074-7613(21)00459-3
doi: 10.1016/j.immuni.2021.10.021
pii:
doi:
Substances chimiques
CXCR3 protein, human
0
Receptors, CXCR3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2842-2858.e5Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests