Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Action Potentials / drug effects Adrenergic alpha-2 Receptor Antagonists / toxicity Arrhythmias, Cardiac / chemically induced Calcium Channels / metabolism Cardiotoxicity Cell Line Dose-Response Relationship, Drug Heart Rate / drug effects Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism Induced Pluripotent Stem Cells / drug effects Myocytes, Cardiac / drug effects Sodium Channels / metabolism Yohimbine / toxicity
Cardiotoxicity Electrophysiology Human-induced pluripotent stem cell-derived cardiomyocytes Yohimbine

Journal

Cardiovascular toxicology
ISSN: 1559-0259
Titre abrégé: Cardiovasc Toxicol
Pays: United States
ID NLM: 101135818

Informations de publication

Date de publication:
02 2022
Historique:
received: 16 08 2021
accepted: 12 11 2021
pubmed: 25 11 2021
medline: 3 3 2022
entrez: 24 11 2021
Statut: ppublish

Résumé

Yohimbine is a highly selective and potent α

Identifiants

DOI: 10.1007/s12012-021-09709-3 PMID: 34817810
pubmed: 34817810
doi: 10.1007/s12012-021-09709-3
pii: 10.1007/s12012-021-09709-3
doi:

Substances chimiques

Adrenergic alpha-2 Receptor Antagonists 0
Calcium Channels 0
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels 0
Sodium Channels 0
Yohimbine 2Y49VWD90Q

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

141-151

Subventions

Organisme : national natural science foundation of china
ID : 82070430
Organisme : shanghai pujiang program
ID : 18PJD031
Organisme : shanghai collaborative innovation center for translational medicine
ID : TM201821
Organisme : natural science foundation of shanghai
ID : 20ZR1434500
Organisme : shanghai science and technology development foundation
ID : PKJ2020-Y06
Organisme : the biomedical engineering fund of shanghai jiao tong university
ID : YG2021GD04
Organisme : national key r&d program of china
ID : (2019YFA0110400)
Organisme : health commission of minhang district, shanghai
ID : 2018MW02

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Références

Anversa, P., Kajstura, J., Rota, M., et al. (2013). Regenerating new heart with stem cells. The Journal of Clinical Investigation, 123, 62–70.
pubmed: 23281411 pmcid: 3533279
Joggerst, S. J., & Hatzopoulos, A. K. (2009). Stem cell therapy for cardiac repair: benefits and barriers. Expert Reviews in Molecular Medicine, 11, e20.
pubmed: 19586557
Magdy, T., Schuldt, A. J. T., Wu, J. C., et al. (2018). Human induced pluripotent stem cell (hiPSC)-derived cells to assess drug cardiotoxicity: Opportunities and problems. Annual Review of Pharmacology and Toxicology, 58, 83–103.
pubmed: 28992430
Burridge, P. W., Li, Y. F., Matsa, E., et al. (2016). Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nature Medicine, 22, 547–556.
pubmed: 27089514 pmcid: 5086256
Sharma, A., Burridge, P. W., McKeithan, W. L., et al. (2017). High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aaf2584
doi: 10.1126/scitranslmed.aaf2584 pubmed: 28904225 pmcid: 5703224
Sharma, A., McKeithan, W. L., Serrano, R., et al. (2018). Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nature Protocols, 13, 3018–3041.
pubmed: 30413796 pmcid: 6502639
McKeithan, W. L., Feyen, D. A. M., Bruyneel, A. A. N., et al. (2020). Reengineering an antiarrhythmic drug using patient hiPSC cardiomyocytes to improve therapeutic potential and reduce toxicity. Cell Stem Cell, 27, 813–21.e6.
pubmed: 32931730 pmcid: 7655512
Yang, L., Gong, Y., Tan, Y., et al. (2021). Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism. Ann Transl Med, 9, 399.
pubmed: 33842620 pmcid: 8033317
Stoelzle, S., Haythornthwaite, A., Kettenhofen, R., et al. (2011). Automated patch clamp on mESC-derived cardiomyocytes for cardiotoxicity prediction. Journal of Biomolecular Screening, 16, 910–916.
pubmed: 21775699
Scheel, O., Frech, S., Amuzescu, B., et al. (2014). Action potential characterization of human induced pluripotent stem cell-derived cardiomyocytes using automated patch-clamp technology. ASSAY and Drug Development Technologies, 12, 457–469.
pubmed: 25353059
Richardson, E. S., & Xiao, Y.-F., et al. (2010). Electrophysiology of single cardiomyocytes: Patch clamp and other recording Methods. In D. C. Sigg, P. A. Iaizzo, & Y.-F. Xiao (Eds.), Cardiac Electrophysiology methods and models (pp. 329–348). Springer, US.
Liu, J., Laksman, Z., & Backx, P. H. (2016). The electrophysiological development of cardiomyocytes. Advanced Drug Delivery Reviews, 96, 253–273.
pubmed: 26788696
Goldberg, M. R., & Robertson, D. (1983). Yohimbine: A pharmacological probe for study of the alpha 2-adrenoreceptor. Pharmacological Reviews, 35, 143–180.
pubmed: 6140686
Ho, C. C. K., & Tan, H. M. (2011). Rise of herbal and traditional medicine in erectile dysfunction management. Current Urology Reports, 12, 470–478.
pubmed: 21948222
Tam, S. W., Worcel, M., & Wyllie, M. (2001). Yohimbine: A clinical review. Pharmacology & Therapeutics, 91, 215–243.
McCarty, M. F. (2002). Pre-exercise administration of Yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Medical Hypotheses, 58, 491–495.
pubmed: 12323115
Ostojic, S. M. (2006). Yohimbine: The effects on body composition and exercise performance in soccer players. Research in Sports Medicine, 14, 289–299.
pubmed: 17214405
Peskind, E. R., Wingerson, D., Murray, S., et al. (1995). Effects of Alzheimer’s disease and normal aging on cerebrospinal fluid norepinephrine responses to Yohimbine and Clonidine. Archives of General Psychiatry, 52, 774–782.
pubmed: 7654129
Petrie, E. C., Peskind, E. R., Dobie, D. J., et al. (2000). Increased plasma norepinephrine response to Yohimbine in elderly men. The Journals of Gerontology: Series A, 55, M155–M159.
Friesen, K., Palatnick, W., & Tenenbein, M. (1993). Benign course after massive ingestion of yohimbine. The Journal of Emergency Medicine, 11, 287–288.
pubmed: 8340584
Linden, C. H., Vellman, W. P., & Rumack, B. (1985). Yohimbine: A new street drug. Annals of Emergency Medicine, 14, 1002–1004.
pubmed: 4037464
Song, J., & Sharman, T. (2019). Yohimbine induced type II myocardial injury: An underrecognized and dangerous adverse effect. American Journal of Medical Case Reports, 7, 271–273.
Giampreti, A., Lonati, D., Locatelli, C., et al. (2009). Acute neurotoxicity after yohimbine ingestion by a body builder. Clinical Toxicology, 47, 827–829.
pubmed: 19640235
Drevin, G., Palayer, M., Compagnon, P., et al. (2020). A fatal case report of acute yohimbine intoxication. Forensic Toxicology, 38, 287–291.
Gu, H., Huang, X., Xu, J., et al. (2018). Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood. Stem Cell Research & Therapy, 9, 163.
Lian, X., Zhang, J., Azarin, S. M., et al. (2013). Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nature Protocols, 8, 162–175.
pubmed: 23257984
Burridge, P. W., Matsa, E., Shukla, P., et al. (2014). Chemically defined generation of human cardiomyocytes. Nature Methods, 11, 855–860.
pubmed: 24930130 pmcid: 4169698
Yang, X., Pabon, L., & Murry, C. E. (2014). Engineering adolescence. Circulation Research, 114, 511–523.
pubmed: 24481842 pmcid: 3955370
Denning, C., Borgdorff, V., Crutchley, J., et al. (2016). Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, 1863, 1728–48.
Bedada, F. B., Wheelwright, M., & Metzger, J. M. (2016). Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes. Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, 1863, 1829–38.
Gong, Y., Chen, Z., Yang, L., et al. (2020). Intrinsic color sensing system allows for real-time observable functional changes on human induced pluripotent stem cell-derived cardiomyocytes. ACS Nano, 14, 8232–8246.
pubmed: 32609489
Zhao, Z., Lan, H., El-Battrawy, I., et al. (2018). Ion channel expression and characterization in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cells International, 2018, 6067096.
pubmed: 29535773 pmcid: 5835237
Paci, M., Hyttinen, J., Rodriguez, B., et al. (2015). Human induced pluripotent stem cell-derived versus adult cardiomyocytes: An in silico electrophysiological study on effects of ionic current block. British Journal of Pharmacology, 172, 5147–5160.
pubmed: 26276951 pmcid: 4629192
Liang, P., Lan, F., Lee, A. S., et al. (2013). Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation, 127, 1677–1691.
pubmed: 23519760
Colatsky, T., Fermini, B., Gintant, G., et al. (2016). The comprehensive in vitro Proarrhythmia Assay (CiPA) initiative—Update on progress. Journal of Pharmacological and Toxicological Methods, 81, 15–20.
pubmed: 27282641
Xiao, R.-P., Zhu, W., Zheng, M., et al. (2006). Subtype-specific α1- and β-adrenoceptor signaling in the heart. Trends in Pharmacological Sciences, 27, 330–337.
pubmed: 16697055
Northover, B. J. (1983). A comparison of the electrophysiological actions of phentolamine with those of some other antiarrhythmic drugs on tissues isolated from the rat heart. British Journal of Pharmacology, 80, 85–93.
pubmed: 6140056 pmcid: 2044962
Azuma, J., Vogel, S., Josephson, I., et al. (1978). Yohimbine blockade of ionic channels in myocardial cells. European Journal of Pharmacology, 51, 109–119.
pubmed: 699977
Hasegawa, J., Hirai, S., Saitoh, M., et al. (1988). Antiarrhythmic effects of alpha-adrenoceptor antagonists in guinea pig ventricular myocardium. Journal of the American College of Cardiology, 12, 1590–1598.
pubmed: 2903873
Satin, J., Kehat, I., Caspi, O., et al. (2004). Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. The Journal of Physiology, 559, 479–496.
pubmed: 15243138 pmcid: 1665128
Poulet, C., Wettwer, E., Grunnet, M., et al. (2015). Late sodium current in human atrial cardiomyocytes from patients in sinus rhythm and atrial fibrillation. PLoS ONE, 10, e0131432.
pubmed: 26121051 pmcid: 4485891
Morad, M., & Zhang, X.-H. (2017). Mechanisms of spontaneous pacing: sinoatrial nodal cells, neonatal cardiomyocytes, and human stem cell derived cardiomyocytes. Canadian Journal of Physiology and Pharmacology, 95, 1100–7.
pubmed: 28350969

Auteurs

Yiqi Gong (Y)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
Center for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.

Li Yang (L)

Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Jun Tang (J)

Department of Anesthesiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China.

Jijian Zheng (J)

Department of Anesthesiology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Nevin Witman (N)

Department of Cell and Molecular Biology, Karolinska Institute, 17177, Stockholm, Sweden.

Philipp Jakob (P)

Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
Center for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952, Schlieren, Switzerland.

Yao Tan (Y)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.

Minglu Liu (M)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.

Ying Chen (Y)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.

Huijing Wang (H)

Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Wei Fu (W)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China. fuweizhulu@163.com.
Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. fuweizhulu@163.com.
Shanghai Key Laboratory of Tissue Engineering, Shanghai 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200011, China. fuweizhulu@163.com.
ORCID: 0000-0003-2321-1057

Wei Wang (W)

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China. wangwei@scmc.com.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes alpha-adrénergiques › Antagonistes des récepteurs alpha-2 adrénergiques › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Cardiotoxicité › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Rythme cardiaque › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux contrôlés par les nucléotides cycliques et activés par l'hyperpolarisation › Yohimbine Directly Induces Cardiotoxicity on...
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questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux sodiques › Yohimbine Directly Induces Cardiotoxicity on...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indolizine › Indolizidines › Alcaloïdes indoliques › Alcaloïdes formés par condensation de sécologanine et de tryptamine › Yohimbine › Yohimbine Directly Induces Cardiotoxicity on...