CD8
Animals
Arthritis, Experimental
/ immunology
Arthritis, Rheumatoid
/ immunology
Autoimmune Diseases
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Cytotoxicity, Immunologic
Disease Models, Animal
Genetic Engineering
HLA-DR1 Antigen
/ genetics
Humans
Immunotherapy, Adoptive
/ methods
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Chimeric Antigen
/ genetics
T-Cell Antigen Receptor Specificity
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
received:
01
07
2021
accepted:
22
10
2021
pubmed:
26
11
2021
medline:
12
1
2022
entrez:
25
11
2021
Statut:
ppublish
Résumé
Ag-specific immunotherapy is a long-term goal for the treatment of autoimmune diseases; however developing a means of therapeutically targeting autoimmune T cells in an Ag-specific manner has been difficult. Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), we have produced CD8
Identifiants
pubmed: 34819392
pii: jimmunol.2100643
doi: 10.4049/jimmunol.2100643
pmc: PMC8702470
mid: NIHMS1751337
doi:
Substances chimiques
HLA-DR1 Antigen
0
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-26Subventions
Organisme : NIAMS NIH HHS
ID : R21 AR071633
Pays : United States
Informations de copyright
Copyright © 2021 by The American Association of Immunologists, Inc.
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