A new experimental model for the investigation of sequential hermaphroditism.
Animals
Anti-Mullerian Hormone
/ genetics
Aromatase Inhibitors
/ pharmacology
Estradiol
/ blood
Female
Fish Proteins
/ genetics
Fishes
/ blood
Gene Expression Regulation
Gonads
/ physiology
Hermaphroditic Organisms
/ drug effects
Male
Models, Animal
Phenotype
Sex Characteristics
Sex Determination Processes
/ drug effects
Social Behavior
Testosterone
/ analogs & derivatives
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 11 2021
24 11 2021
Historique:
received:
17
08
2021
accepted:
08
11
2021
entrez:
25
11
2021
pubmed:
26
11
2021
medline:
3
2
2022
Statut:
epublish
Résumé
The stunning sexual transformation commonly triggered by age, size or social context in some fishes is one of the best examples of phenotypic plasticity thus far described. To date our understanding of this process is dominated by studies on a handful of subtropical and tropical teleosts, often in wild settings. Here we have established the protogynous New Zealand spotty wrasse, Notolabrus celidotus, as a temperate model for the experimental investigation of sex change. Captive fish were induced to change sex using aromatase inhibition or manipulation of social groups. Complete female-to-male transition occurred over 60 days in both cases and time-series sampling was used to quantify changes in hormone production, gene expression and gonadal cellular anatomy. Early-stage decreases in plasma 17β-estradiol (E2) concentrations or gonadal aromatase (cyp19a1a) expression were not detected in spotty wrasse, despite these being commonly associated with the onset of sex change in subtropical and tropical protogynous (female-to-male) hermaphrodites. In contrast, expression of the masculinising factor amh (anti-Müllerian hormone) increased during early sex change, implying a potential role as a proximate trigger for masculinisation. Collectively, these data provide a foundation for the spotty wrasse as a temperate teleost model to study sex change and cell fate in vertebrates.
Identifiants
pubmed: 34819550
doi: 10.1038/s41598-021-02063-y
pii: 10.1038/s41598-021-02063-y
pmc: PMC8613207
doi:
Substances chimiques
Aromatase Inhibitors
0
Fish Proteins
0
Testosterone
3XMK78S47O
Estradiol
4TI98Z838E
Anti-Mullerian Hormone
80497-65-0
11-ketotestosterone
KF38W1A85U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22881Subventions
Organisme : University of Otago Research
ID : ORG 0117-0318
Organisme : Research Enhancement
ID : PBRF-ML63
Organisme : Marsden Fund
ID : UOO1308
Informations de copyright
© 2021. The Author(s).
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