Lipotoxicity Disrupts Erythrocyte Function: A Perspective.
Erythrocytes
atherosclerosis.
cardiometabolic diseases
lipid accumulation
lipotoxicity
oxidized phospholipids
Journal
Cardiovascular & hematological disorders drug targets
ISSN: 2212-4063
Titre abrégé: Cardiovasc Hematol Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269160
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
10
2020
revised:
25
02
2021
accepted:
15
03
2021
pubmed:
27
11
2021
medline:
14
1
2022
entrez:
26
11
2021
Statut:
ppublish
Résumé
Lipid accumulation in the liver, skeletal and cardiac muscle, kidneys and pancreas causes cell dysfunction, death and inflammation, a biological phenomenon named lipotoxicity. Erythrocytes participate in the transport of lipids in the circulation, and their lipidome is determined by exchange with blood components. The objective of this study is to summarize the current knowledge regarding the effect of toxic lipid accumulation in erythrocytes. Erythrocyte lipidome is altered in lipotoxic diseases, such as fatty liver disease, heart failure and diabetes. In addition, ceramide, lysophosphatidylcholine, lysophosphatidic acid, palmitic acid and free cholesterol induce erythrocyte malfunction. Erythrocytes are an additional cell target of lipotoxicity. Further exploration of the implicated molecular mechanisms could lead to novel therapeutic targets for cardiometabolic and hematological diseases.
Sections du résumé
BACKGROUND
Lipid accumulation in the liver, skeletal and cardiac muscle, kidneys and pancreas causes cell dysfunction, death and inflammation, a biological phenomenon named lipotoxicity. Erythrocytes participate in the transport of lipids in the circulation, and their lipidome is determined by exchange with blood components.
OBJECTIVE
The objective of this study is to summarize the current knowledge regarding the effect of toxic lipid accumulation in erythrocytes.
RESULTS
Erythrocyte lipidome is altered in lipotoxic diseases, such as fatty liver disease, heart failure and diabetes. In addition, ceramide, lysophosphatidylcholine, lysophosphatidic acid, palmitic acid and free cholesterol induce erythrocyte malfunction.
CONCLUSION
Erythrocytes are an additional cell target of lipotoxicity. Further exploration of the implicated molecular mechanisms could lead to novel therapeutic targets for cardiometabolic and hematological diseases.
Identifiants
pubmed: 34825642
pii: CHDDT-EPUB-116798
doi: 10.2174/1871529X21666210719125728
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-94Informations de copyright
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