A Study on Synthesis and Upscaling of 2'-

Cytidine / analogs & derivatives Oligonucleotides / chemical synthesis Organophosphorus Compounds / chemistry Uridine / analogs & derivatives
2′-O-(N-(aminoethyl)carbamoyl)methyl modification 5-methylcytidine 5-methyluridine alkylation monoacetylation oligonucleotides phase transfer catalysis (PTC)

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
17 Nov 2021
Historique:
received: 15 10 2021
revised: 11 11 2021
accepted: 14 11 2021
entrez: 27 11 2021
pubmed: 28 11 2021
medline: 15 12 2021
Statut: epublish

Résumé

2'-

Identifiants

DOI: 10.3390/molecules26226927 PMID: 34834019 PMC: PMC8619030
pubmed: 34834019
pii: molecules26226927
doi: 10.3390/molecules26226927
pmc: PMC8619030
pii:
doi:

Substances chimiques

Oligonucleotides 0
Organophosphorus Compounds 0
phosphoramidite 0
ribothymidine 1463-10-1
Cytidine 5CSZ8459RP
5-methylcytidine TL9PB228DC
Uridine WHI7HQ7H85

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Union
ID : 721613

Références

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pubmed: 20183563
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pubmed: 15547979
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pubmed: 16270660
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pubmed: 16111635
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pubmed: 28334758
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Auteurs

Kristina Karalė (K)

Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.
RISE, Department Chemical Process and Pharmaceutical Development, Forskargatan 18, 151 36 Södertälje, Sweden.
ORCID: 0000-0002-4366-5833

Martin Bollmark (M)

RISE, Department Chemical Process and Pharmaceutical Development, Forskargatan 18, 151 36 Södertälje, Sweden.

Rouven Stulz (R)

Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.
Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, 431 50 Gothenburg, Sweden.

Dmytro Honcharenko (D)

Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.

Ulf Tedebark (U)

RISE, Department Chemical Process and Pharmaceutical Development, Forskargatan 18, 151 36 Södertälje, Sweden.
ORCID: 0000-0002-9098-6410

Roger Strömberg (R)

Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.
ORCID: 0000-0002-7902-2688

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Cytidine › A Study on Synthesis and Upscaling of 2'-
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › A Study on Synthesis and Upscaling of 2'-
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › A Study on Synthesis and Upscaling of 2'-
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › A Study on Synthesis and Upscaling of 2'-