Vitamins as Possible Cancer Biomarkers: Significance and Limitations.
cancer biomarker
cancer risk
vitamin A
vitamin B complex
vitamin C
vitamin D
vitamin E
vitamin K
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
01 Nov 2021
01 Nov 2021
Historique:
received:
21
09
2021
revised:
28
10
2021
accepted:
29
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The Western-style diet, which is common in developed countries and spreading into developing countries, is unbalanced in many respects. For instance, micronutrients (vitamins A, B complex, C, D, E, and K plus iron, zinc, selenium, and iodine) are generally depleted in Western food (causing what is known as 'hidden hunger'), whereas some others (such as phosphorus) are added beyond the daily allowance. This imbalance in micronutrients can induce cellular damage that can increase the risk of cancer. Interestingly, there is a large body of evidence suggesting a strong correlation between vitamin intake as well as vitamin blood concentrations with the occurrence of certain types of cancer. The direction of association between the concentration of a given vitamin and cancer risk is tumor specific. The present review summarized the literature regarding vitamins and cancer risk to assess whether these could be used as diagnostic or prognostic markers, thus confirming their potential as biomarkers. Despite many studies that highlight the importance of monitoring vitamin blood or tissue concentrations in cancer patients and demonstrate the link between vitamin intake and cancer risk, there is still an urgent need for more data to assess the effectiveness of vitamins as biomarkers in the context of cancer. Therefore, this review aims to provide a solid basis to support further studies on this promising topic.
Identifiants
pubmed: 34836171
pii: nu13113914
doi: 10.3390/nu13113914
pmc: PMC8622959
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Micronutrients
0
Vitamins
0
Vitamin A
11103-57-4
Vitamin B Complex
12001-76-2
Vitamin K
12001-79-5
Vitamin E
1406-18-4
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Rural Affairs and Consumer Protection Baden-Wuerttemberg
ID : AZ: 34-9185.90-1
Organisme : Else-Uebelmesser-Stiftung
ID : D3021947; reference: GzV 1.14
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