Association between aortic calcification and the presence of kidney stones: calcium oxalate calculi in focus.
Aortic calcification
Calcium oxalate calculi
Nephrolithiasis
Screened population
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
09
05
2021
accepted:
11
11
2021
pubmed:
1
12
2021
medline:
12
7
2022
entrez:
30
11
2021
Statut:
ppublish
Résumé
The current research is aimed at analyzing the relationship between kidney stone (KS) and abdominal aortic calcification (AAC) and the relationship between KS components and AAC. This is a retrospective, case-control study. Kidney stone formers (KSFs) were treated at the Department of Urology, West China Hospital, Sichuan University for urological calculus disease from January 2014 to January 2020. Matched non-stone formers (non-SFs) were drawn from the same hospital for routine health examination from January 2018 to February 2019. Research-related information was collected and reviewed retrospectively from the hospital's computerized records. AAC were evaluated using available results of computed tomography imaging and abdominal vascular ultrasound. The relationships of AAC between KSFs and non-SFs were compared. The composition of renal calculi was analyzed by Fourier-transform infrared spectrophotometer. KSFs were divided into AAC groups and non-AAC based on AAC. The relationship of the composition of renal calculi between AAC and non-AAC were compared. The independent-sample t test, the chi-squared test and binary logistics regression were performed. Altogether, 4516 people were included, with 1027 KSFs and 3489 non-SFs. There were no significant differences in the laboratory parameters between KSFs and non-SFs. The association between the presence of AAC and KS was significant in multivariable model 2 [adjusting hypertension, diabetes mellitus, fasting blood glucose, uric acid, serum triglyceride (TG), serum calcium, and urine pH] (OR 5.756, 95% CI 4.616-7.177, p < 0.001). The result of KSFs showed that calcium oxalate calculi (CaOx) was significantly associated with AAC in multivariable model 3 (adjusting age, hypertension, diabetes mellitus, drinking history, smoking history, and TG) (OR 1.351, 95% CI 1.002-1.822, p = 0.048). The current study pioneered the revelation of the relationship between CaOx and AAC. Through an elimination of the confounding factors, the study demonstrated that KS and AAC were connected.
Identifiants
pubmed: 34846621
doi: 10.1007/s11255-021-03058-4
pii: 10.1007/s11255-021-03058-4
pmc: PMC9262773
doi:
Substances chimiques
Calcium Oxalate
2612HC57YE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1915-1923Subventions
Organisme : The National Natural Science Fund of China
ID : 81770703
Organisme : The National Natural Science Fund of China
ID : 81970602
Organisme : Project of Science and Technology Department of Sichuan Province
ID : 2021YFS0116
Organisme : 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
ID : ZYJC18015
Organisme : Project of Guangzhou Medical University
ID : HX-H1701002
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. The Author(s).
Références
Am J Physiol Renal Physiol. 2019 Jul 1;317(7):F65-F72
pubmed: 31017011
JAMA. 2013 Jul 24;310(4):408-15
pubmed: 23917291
J Biol Chem. 2005 Oct 21;280(42):35704-12
pubmed: 16109715
Sci Rep. 2016 Oct 12;6:35167
pubmed: 27731368
Int J Biol Sci. 2014 May 01;10(5):520-9
pubmed: 24910531
Rev Urol. 2010 Spring;12(2-3):e86-96
pubmed: 20811557
ScientificWorldJournal. 2014;2014:637065
pubmed: 25136676
Eur Urol. 2012 Jul;62(1):160-5
pubmed: 22498635
Kidney Int. 2004 Jan;65(1):154-61
pubmed: 14675046
J Urol. 2011 Apr;185(4):1304-11
pubmed: 21334658
J Cardiovasc Dev Dis. 2015;2(3):141-164
pubmed: 26185749
Kidney Int. 2006 Apr;69(8):1313-8
pubmed: 16614720
Clin J Am Soc Nephrol. 2015 Feb 6;10(2):278-85
pubmed: 25635036
Kidney Int. 2002 Jan;61(1):105-12
pubmed: 11786090
PLoS One. 2015 Sep 02;10(9):e0137350
pubmed: 26332888
Int J Mol Sci. 2019 Apr 04;20(7):
pubmed: 30987410
J Endourol. 2017 Sep;31(9):956-961
pubmed: 28605936
Urolithiasis. 2015 Jan;43 Suppl 1:109-23
pubmed: 25119506
J Urol. 2016 Apr;195(4 Pt 1):971-6
pubmed: 26454103
Am J Kidney Dis. 2017 Aug;70(2):158-159
pubmed: 28739125
Nephron Physiol. 2004;98(2):p43-7
pubmed: 15499214
J Nephrol. 2019 Aug;32(4):589-594
pubmed: 31165423
Sci Rep. 2015 Oct 26;5:15272
pubmed: 26497088
Kidney Int. 2013 Mar;83(3):479-86
pubmed: 23283137
Urolithiasis. 2015 Jan;43 Suppl 1:41-5
pubmed: 25475492
Coron Artery Dis. 2011 May;22(3):179-87
pubmed: 21407077
Radiology. 2006 Jul;240(1):110-5
pubmed: 16793974
Int J Mol Sci. 2019 Dec 17;20(24):
pubmed: 31861118
Int J Mol Sci. 2020 Mar 23;21(6):
pubmed: 32210002
Nephron Physiol. 2004;97(1):p23-30
pubmed: 15153748
J Urol. 2012 Mar;187(3):1094-100
pubmed: 22266007
Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1029-34
pubmed: 12730087
Eur Urol. 2000 Mar;37(3):339-44
pubmed: 10720863
Eur Urol. 2016 Mar;69(3):468-74
pubmed: 26318710
Clin Cases Miner Bone Metab. 2008 May;5(2):107-9
pubmed: 22460990
BJU Int. 2013 Nov;112 Suppl 2:65-8
pubmed: 24127678
J Urol. 2016 Oct;196(4):1153-60
pubmed: 27238616
Urol Res. 2011 Oct;39(5):339-43
pubmed: 21249491
J Endourol. 2019 Dec;33(12):1032-1034
pubmed: 31220925
Nanomedicine (Lond). 2016 Sep;11(18):2399-404
pubmed: 27498926
Eur Urol. 2015 Apr;67(4):750-63
pubmed: 25454613
Best Pract Res Clin Endocrinol Metab. 2010 Aug;24(4):527-39
pubmed: 20832734