Redefining intestinal immunity with single-cell transcriptomics.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
15
07
2021
accepted:
03
11
2021
revised:
27
10
2021
pubmed:
2
12
2021
medline:
9
7
2022
entrez:
1
12
2021
Statut:
ppublish
Résumé
The intestinal immune system represents the largest collection of immune cells in the body and is continually exposed to antigens from food and the microbiota. Here we discuss the contribution of single-cell transcriptomics in shaping our understanding of this complex system. We consider the impact on resolving early intestine development, engagement with the neighbouring microbiota, diversity of intestinal immune cells, compartmentalisation within the intestines and interactions with non-immune cells. Finally, we offer a perspective on open questions about gut immunity that evolving single-cell technologies are well placed to address.
Identifiants
pubmed: 34848830
doi: 10.1038/s41385-021-00470-y
pii: S1933-0219(22)00079-4
pmc: PMC8630196
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
531-541Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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