Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.
CD8+ T cells
COVID-19
SARS-CoV-2
apoptosis
lymphopenia
phosphatidylserine
platelet-derived microparticle
thromboinflammation
Journal
Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
30
09
2021
accepted:
02
11
2021
entrez:
2
12
2021
pubmed:
3
12
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Infection with SARS-CoV-2 is associated with thromboinflammation, involving thrombotic and inflammatory responses, in many COVID-19 patients. In addition, immune dysfunction occurs in patients characterised by T cell exhaustion and severe lymphopenia. We investigated the distribution of phosphatidylserine (PS), a marker of dying cells, activated platelets and platelet-derived microparticles (PMP), during the clinical course of COVID-19. We found an unexpectedly high amount of blood cells loaded with PS
Identifiants
pubmed: 34854246
doi: 10.1002/jev2.12173
pmc: PMC8636722
doi:
Substances chimiques
Phosphatidylserines
0
Platelet Membrane Glycoprotein IIb
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12173Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
ID : Project-ID 210592381 - SFB 1054: TP B03
Organisme : Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
ID : A06
Organisme : Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
ID : Project-ID 369799452 - SFB/TR237: TP B14
Organisme : Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
ID : Project-ID 391217598 - KR2199/10-1
Organisme : Bavarian State Ministry of Science and the Arts
Informations de copyright
© 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
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