Allosteric receptor modulation uncovers an FFA2R antagonist as a positive orthosteric modulator/agonist in disguise.

Allosteric Regulation Calcium / pharmacology Fatty Acids, Nonesterified Neutrophils Receptors, Cell Surface Signal Transduction
Allosteric modulation Free fatty acid G protein-coupled receptor Inflammation NADPH-oxidase Neutrophil Orthosteric agonist independent activation Receptor cross talk

Journal

Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683

Informations de publication

Date de publication:
02 2022
Historique:
received: 02 10 2021
revised: 23 11 2021
accepted: 25 11 2021
pubmed: 3 12 2021
medline: 1 4 2022
entrez: 2 12 2021
Statut: ppublish

Résumé

A novel receptor crosstalk activation mechanism, through which signals generated by the agonist-occupied P2Y

Identifiants

DOI: 10.1016/j.cellsig.2021.110208 PMID: 34856356
pubmed: 34856356
pii: S0898-6568(21)00297-7
doi: 10.1016/j.cellsig.2021.110208
pii:
doi:

Substances chimiques

Fatty Acids, Nonesterified 0
Receptors, Cell Surface 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110208

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Simon Lind (S)

Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

Dagny Olofsson Hoffmann (DO)

Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

Huamei Forsman (H)

Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

Claes Dahlgren (C)

Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address: Claes.Dahlgren@microbio.gu.se.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Allosteric receptor modulation uncovers an...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Allosteric receptor modulation uncovers an...
questionsmedicales.fr › Lipides › Acides gras › Acide gras libre › Allosteric receptor modulation uncovers an...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Allosteric receptor modulation uncovers an...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Allosteric receptor modulation uncovers an...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Allosteric receptor modulation uncovers an...