High Frequencies of Functional Virus-Specific CD4
Ageusia
/ pathology
Anosmia
/ pathology
Antibodies, Viral
/ blood
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
COVID-19
/ immunology
Cytokines
/ blood
Humans
Interferon-gamma
/ blood
SARS-CoV-2
/ immunology
Spike Glycoprotein, Coronavirus
/ immunology
CD4 and CD8
COVID - 19
IFN gamma
SARS- CoV-2
anosmia
virus specific T cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
07
2021
accepted:
20
10
2021
entrez:
3
12
2021
pubmed:
4
12
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Olfactory and taste disorders (OTD) are commonly found as presenting symptoms of SARS-CoV-2 infection in patients with clinically mild COVID-19. Virus-specific T cells are thought to play an important role in the clearance of SARS-CoV-2; therefore the study of T cell specific immune responses in patients with mild symptoms may help to understand their possible role in protection from severe disease. We evaluated SARS-CoV-2-specific T cell responses to four different peptide megapools covering all SARS-CoV-2 proteins during the acute phase of the disease in 33 individuals with mild or no other symptom beside OTD and in 22 age-matched patients with severe infection. A control group of 15 outpatients with OTD and consistently negative nasopharyngeal SARS-CoV-2 RNA swabs and virus-specific IgG serology was included in the study. Increased frequencies of virus-specific CD4
Identifiants
pubmed: 34858405
doi: 10.3389/fimmu.2021.748881
pmc: PMC8631501
doi:
Substances chimiques
Antibodies, Viral
0
Cytokines
0
IFNG protein, human
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
748881Informations de copyright
Copyright © 2021 Mele, Calastri, Maiorano, Cerino, Sachs, Oliviero, Mantovani, Baldanti, Bruno, Benazzo, Grifoni, Sette, Mondelli and Varchetta.
Déclaration de conflit d'intérêts
AS is a consultant for Gritstone, Flow Pharma, Arcturus, Immunoscape, 20 CellCarta, OxfordImmunotech and Avalia. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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