METTLing in the right place: METTL8 is a mitochondrial tRNA-specific methyltransferase.

Mitochondria / genetics Protein Biosynthesis RNA, Messenger / metabolism RNA, Transfer / genetics tRNA Methyltransferases / genetics

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
02 12 2021
Historique:
entrez: 3 12 2021
pubmed: 4 12 2021
medline: 24 12 2021
Statut: ppublish

Résumé

Schöller et al. (2021) discovered that METTL8, thought of as an mRNA modifier, is a tRNA-specific mitochondrial enzyme important for mitochondrial translation and function. Paradoxically, increased expression of METTL8 is associated with high respiratory rates in pancreatic cancers.

Identifiants

DOI: 10.1016/j.molcel.2021.11.009 PMID: 34861186
pubmed: 34861186
pii: S1097-2765(21)00978-3
doi: 10.1016/j.molcel.2021.11.009
pii:
doi:

Substances chimiques

RNA, Messenger 0
RNA, Transfer 9014-25-9
tRNA Methyltransferases EC 2.1.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

4765-4767

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Eva Kowalinski (E)

EMBL Grenoble, 71 Avenue des Martyrs, 38042 Grenoble, France.

Juan D Alfonzo (JD)

Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA. Electronic address: alfonzo.1@osu.edu.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › METTLing in the right place: METTL8 is a...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › METTLing in the right place: METTL8 is a...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › METTLing in the right place: METTL8 is a...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN de transfert › METTLing in the right place: METTL8 is a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › T-RNA methyltransferases › METTLing in the right place: METTL8 is a...