Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels.

Brain / diagnostic imaging Humans Intermediate Filaments Magnetic Resonance Imaging Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging White Matter / diagnostic imaging
Brain Clinically isolated syndrome Diffusely abnormal white matter MRI Multiple sclerosis Neurofilament

Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 31 05 2021
revised: 23 10 2021
accepted: 20 11 2021
pubmed: 7 12 2021
medline: 17 2 2022
entrez: 6 12 2021
Statut: ppublish

Résumé

We characterized the frequency of diffusely abnormal white matter (DAWM) across a broad spectrum of multiple sclerosis (MS) participants. 35% of clinically isolated syndrome (CIS), 57% of relapsing remitting and 64% of secondary progressive MS participants demonstrated DAWM. CIS with DAWM had decreased cortical thickness, higher lesion load and a higher concentration of serum neurofilament light chain compared to CIS without DAWM. DAWM may be useful in identifying CIS patients with greater injury to their brains. Larger and longitudinal studies are warranted.

Identifiants

DOI: 10.1016/j.msard.2021.103422 PMID: 34871858
pubmed: 34871858
pii: S2211-0348(21)00688-X
doi: 10.1016/j.msard.2021.103422
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103422

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

I M Vavasour (IM)

Radiology, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: lees@physics.ubc.ca.

P Becquart (P)

Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

J Gill (J)

Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

G Zhao (G)

MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada.

J T Yik (JT)

International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; Physics & Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.

A Traboulsee (A)

MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

R L Carruthers (RL)

Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

S H Kolind (SH)

Radiology, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Physics & Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.

A J Schabas (AJ)

Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

A L Sayao (AL)

Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

V Devonshire (V)

Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

R Tam (R)

Radiology, University of British Columbia, Vancouver, British Columbia, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada.

G R W Moore (GRW)

International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

S Stukas (S)

Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

C L Wellington (CL)

Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

J A Quandt (JA)

Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

D K B Li (DKB)

Radiology, University of British Columbia, Vancouver, British Columbia, Canada; MS/MRI Research Group, University of British Columbia, Vancouver, British Columbia, Canada; Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

C Laule (C)

Radiology, University of British Columbia, Vancouver, British Columbia, Canada; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Physics & Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Diffusely abnormal white matter in clinically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diffusely abnormal white matter in clinically...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Filaments intermédiaires › Diffusely abnormal white matter in clinically...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Diffusely abnormal white matter in clinically...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Diffusely abnormal white matter in clinically...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Sclérose en plaques récurrente-rémittente › Diffusely abnormal white matter in clinically...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Diffusely abnormal white matter in clinically...