The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics.
Adenocarcinoma
/ genetics
Aged
Carcinoma, Large Cell
/ genetics
Carcinoma, Neuroendocrine
/ genetics
Carcinoma, Non-Small-Cell Lung
/ genetics
Carcinoma, Squamous Cell
/ genetics
Cell Line, Tumor
Gene Expression Profiling
/ methods
Gene Expression Regulation, Neoplastic
Genomics
/ methods
Humans
Lung Neoplasms
/ classification
Middle Aged
Phenotype
Small Cell Lung Carcinoma
/ genetics
Transcriptome
/ genetics
Exome Sequencing
/ methods
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 12 2021
06 12 2021
Historique:
received:
14
01
2021
accepted:
16
11
2021
entrez:
7
12
2021
pubmed:
8
12
2021
medline:
11
1
2022
Statut:
epublish
Résumé
Histology plays an essential role in therapeutic decision-making for lung cancer patients. However, the molecular determinants of lung cancer histology are largely unknown. We conduct whole-exome sequencing and microarray profiling on 19 micro-dissected tumor regions of different histologic subtypes from 9 patients with lung cancers of mixed histology. A median of 68.9% of point mutations and 83% of copy number aberrations are shared between different histologic components within the same tumors. Furthermore, different histologic components within the tumors demonstrate similar subclonal architecture. On the other hand, transcriptomic profiling reveals shared pathways between the same histologic subtypes from different patients, which is supported by the analyses of the transcriptomic data from 141 cell lines and 343 lung cancers of different histologic subtypes. These data derived from mixed histologic subtypes in the setting of identical genetic background and exposure history support that the histologic fate of lung cancer cells is associated with transcriptomic features rather than the genomic profiles in most tumors.
Identifiants
pubmed: 34873156
doi: 10.1038/s41467-021-27341-1
pii: 10.1038/s41467-021-27341-1
pmc: PMC8648877
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7081Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA070907
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA234629
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009666
Pays : United States
Informations de copyright
© 2021. The Author(s).
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