Towards understanding the extensive diversity of protein N-glycan structures in eukaryotes.
Golgi apparatus
N-glycans
calcium homeostasis
endoplasmic reticulum
eukaryotes
glycosylation
glycosyltransferases
manganese homeostasis
regulation
structural diversity
Journal
Biological reviews of the Cambridge Philosophical Society
ISSN: 1469-185X
Titre abrégé: Biol Rev Camb Philos Soc
Pays: England
ID NLM: 0414576
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
04
11
2021
received:
05
05
2021
accepted:
24
11
2021
pubmed:
8
12
2021
medline:
3
5
2022
entrez:
7
12
2021
Statut:
ppublish
Résumé
N-glycosylation is an important post-translational modification of proteins that has been highly conserved during evolution and is found in Eukaryota, Bacteria and Archaea. In eukaryotes, N-glycan processing is sequential, involving multiple specific steps within the secretory pathway as proteins travel through the endoplasmic reticulum and the Golgi apparatus. In this review, we first summarize the different steps of the N-glycan processing and further describe recent findings regarding the diversity of N-glycan structures in eukaryotic clades. This comparison allows us to explore the different regulation mechanisms of N-glycan processing among eukaryotic clades. Recent findings regarding the regulation of protein N-glycosylation are highlighted, especially the regulation of the biosynthesis of complex-type N-glycans through manganese and calcium homeostasis and the specific role of transmembrane protein 165 (TMEM165) for which homologous sequences have been identified in several eukaryotic clades. Further research will be required to characterize the function of TMEM165 homologous sequences in different eukaryotic clades.
Identifiants
pubmed: 34873817
doi: 10.1111/brv.12820
pmc: PMC9300197
doi:
Substances chimiques
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
732-748Informations de copyright
© 2021 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.
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