Nonstandard RNA/RNA interactions likely enhance folding and stability of segmented ribosomes.
kinetoplastids
nonstandard RNA interactions
segmented ribosomes
trypanosomatid
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
03
10
2021
accepted:
26
11
2021
pubmed:
9
12
2021
medline:
5
3
2022
entrez:
8
12
2021
Statut:
ppublish
Résumé
The ribosome is the molecular factory that catalyzes all coded protein synthesis in extant organisms. Eukaryotic ribosomes are typically assembled out of four rRNAs; namely, 5S, 5.8S, 18S, and 28S. However, the 28S rRNA of some trypanosomatid organisms has been found to be segmented into six independent rRNAs of different sizes. The two largest segments have multiple sites where they jointly form stems comprised of standard base pairs that can hold them together. However, such regions of interaction are not observed among the four smaller RNAs. Early reports suggested that trypanosomatid segmented ribosome assembly was essentially achieved thanks to their association with rProteins. However, examination of cryo-EM ribosomal structures from
Identifiants
pubmed: 34876487
pii: rna.079006.121
doi: 10.1261/rna.079006.121
pmc: PMC8848935
doi:
Substances chimiques
RNA, Ribosomal
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
340-352Subventions
Organisme : Intramural NASA
ID : 80NSSC18K1139
Pays : United States
Informations de copyright
© 2022 Rivas and Fox; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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