Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update.
breast cancer
calcitriol
drug combination
efficacy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
20
10
2021
revised:
16
11
2021
accepted:
19
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Preclinical, clinical, and epidemiological studies indicate that vitamin D3 (VD) deficiency is a risk factor for the development of breast cancer. Underlying mechanisms include the ability of calcitriol to induce cell differentiation, inhibit oncogenes expression, and modify different signaling pathways involved in the control of cell proliferation. In addition, calcitriol combined with different kinds of antineoplastic drugs has been demonstrated to enhance their beneficial effects in an additive or synergistic fashion. However, a recognized adjuvant regimen based on calcitriol for treating patients with breast cancer has not yet been fully established. Accordingly, in the present work, we review and discuss the preclinical and clinical studies about the combination of calcitriol with different oncological drugs, aiming to emphasize its main therapeutic benefits and opportunities for the treatment of this pathology.
Identifiants
pubmed: 34884550
pii: ijms222312741
doi: 10.3390/ijms222312741
pmc: PMC8657847
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Bone Density Conservation Agents
0
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : 256994
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : A1-S-10749
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