Indazole Derivatives Effective against Gastrointestinal Diseases.
Diarrhea
Gastrointestinal cancer
Indazole
Irritable bowel syndrome
Metabolic syndrome
Ulcerative colitis
Journal
Current topics in medicinal chemistry
ISSN: 1873-4294
Titre abrégé: Curr Top Med Chem
Pays: United Arab Emirates
ID NLM: 101119673
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
07
2021
revised:
03
11
2021
accepted:
13
11
2021
pubmed:
11
12
2021
medline:
19
8
2022
entrez:
10
12
2021
Statut:
ppublish
Résumé
In this fast-growing lifestyle, humans are in the race against time to cope up with busy schedule. Less exercise, consumption of high calorie-low fiber food and stress take us one step closer towards digestive dysfunction. Dysfunctional digestive system causes various gastrointestinal disorders like constipation, IBS, UC, diarrhea, gastrointestinal tract immobility, hyperglycemia, hemorrhoids, fistula, anal fissures, stomach cancer, hepatocellular carcinoma, pancreatic cancer, colon cancer and metabolic syndrome. Amongst various natural and synthetic indazole derivatives nigellicine, nigellamine, nigellidine, zanubrutinib and SCH772984 showed prominent results to cure various gastrointestinal disorders. In this manuscript, we focus on the importance of indazole derivatives in the treatment of various gastrointestinal diseases. In the treatment of IBS, four positions (R
Sections du résumé
BACKGROUND
BACKGROUND
In this fast-growing lifestyle, humans are in the race against time to cope up with busy schedule. Less exercise, consumption of high calorie-low fiber food and stress take us one step closer towards digestive dysfunction. Dysfunctional digestive system causes various gastrointestinal disorders like constipation, IBS, UC, diarrhea, gastrointestinal tract immobility, hyperglycemia, hemorrhoids, fistula, anal fissures, stomach cancer, hepatocellular carcinoma, pancreatic cancer, colon cancer and metabolic syndrome. Amongst various natural and synthetic indazole derivatives nigellicine, nigellamine, nigellidine, zanubrutinib and SCH772984 showed prominent results to cure various gastrointestinal disorders.
OBJECTIVES
OBJECTIVE
In this manuscript, we focus on the importance of indazole derivatives in the treatment of various gastrointestinal diseases.
RESULTS AND CONCLUSION
CONCLUSIONS
In the treatment of IBS, four positions (R
Identifiants
pubmed: 34886775
pii: CTMC-EPUB-119325
doi: 10.2174/1568026621666211209155933
doi:
Substances chimiques
Benzamides
0
Formamides
0
Indazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1189-1214Informations de copyright
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