Vaginal microbiota of American Indian women and associations with measures of psychosocial stress.
Adult
Bacteria
/ classification
DNA, Bacterial
/ genetics
DNA, Ribosomal
/ genetics
Female
Humans
Microbiota
Middle Aged
Phylogeny
Prevalence
RNA, Ribosomal, 16S
/ genetics
Sequence Analysis, DNA
/ methods
Stress, Psychological
/ epidemiology
United States
/ ethnology
Vagina
/ microbiology
Vaginosis, Bacterial
/ epidemiology
Young Adult
American Indian or Alaska Native
/ statistics & numerical data
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
02
2021
accepted:
17
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
8
1
2022
Statut:
epublish
Résumé
Molecular-bacterial vaginosis (BV) is characterized by low levels of vaginal Lactobacillus species and is associated with higher risk of sexually transmitted infections (STI). Perceived psychosocial stress is associated with increased severity and persistence of infections, including STIs. American Indians have the highest rates of stress and high rates of STIs. The prevalence of molecular-BV among American Indian women is unknown. We sought to evaluate measures of psychosocial stress, such as historic loss (a multigenerational factor involving slavery, forced removal from one's land, legally ratified race-based segregation, and contemporary discrimination) and their association with the vaginal microbiota and specific metabolites associated with BV, in 70 Northwestern Plains American Indian women. Demographics, perceived psychosocial stressors, sexual practices, and known BV risk factors were assessed using a modified version of the American Indian Service Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project survey. Self-collected mid-vaginal swabs were profiled for bacterial composition by 16S rRNA gene amplicon sequencing and metabolites quantified by targeted liquid-chromatography mass spectrometry. Sixty-six percent of the participants were classified as having molecular-BV, with the rest being either dominated by L. crispatus (10%) or L. iners (24%). High levels of lifetime trauma were associated with higher odds of having molecular-BV (adjusted Odds Ratio (aOR): 2.5, 95% Credible Interval (CrI): 1.1-5.3). Measures of psychosocial stress, including historic loss and historic loss associated symptoms, were significantly associated with lifestyle and behavioral practices. Higher scores of lifetime trauma were associated with increased concentrations of spermine (aFC: 3.3, 95% CrI: 1.2-9.2). Historic loss associated symptoms and biogenic amines were the major correlates of molecular-BV. Historical loss associated symptoms and lifetime trauma are potentially important underlying factors associated with BV.
Identifiants
pubmed: 34890405
doi: 10.1371/journal.pone.0260813
pii: PONE-D-21-03745
pmc: PMC8664215
doi:
Substances chimiques
DNA, Bacterial
0
DNA, Ribosomal
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0260813Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103474
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116799
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI111145
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115371
Pays : United States
Déclaration de conflit d'intérêts
JR is the co‐ founder of LUCA Biologics, a biotechnology company focusing on translating microbiome research into live biotherapeutic drugs for women’s health. All other authors have declared that no competing interests exist.
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