Improving Analysis and Annotation of Microarray Data with Protein Interactions.

Biological Phenomena Computational Biology Gene Expression Profiling Microarray Analysis Molecular Sequence Annotation
Gene expression Gene expression analysis Network analysis Protein–protein interactions

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2022
Historique:
entrez: 13 12 2021
pubmed: 14 12 2021
medline: 27 1 2022
Statut: ppublish

Résumé

Gene expression microarrays are one of the most widely used high-throughput technologies in molecular biology, with applications such as identification of disease mechanisms and development of diagnostic and prognostic gene signatures. However, the success of these tasks is often limited because microarray analysis does not account for the complex relationships among genes, their products, and overall signaling and regulatory cascades. Incorporating protein-protein interaction data into microarray analysis can help address these challenges. This chapter reviews how protein-protein interactions can help with microarray analysis, leading to benefits such as better explanations of disease mechanisms, more complete gene annotations, improved prioritization of genes for future experiments, and gene signatures that generalize better to new data.

Identifiants

DOI: 10.1007/978-1-0716-1839-4_5 PMID: 34902122
pubmed: 34902122
doi: 10.1007/978-1-0716-1839-4_5
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

51-68

Informations de copyright

© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Max Kotlyar (M)

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Serene W H Wong (SWH)

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Chiara Pastrello (C)

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Igor Jurisica (I)

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada. juris@ai.utoronto.ca.
Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. juris@ai.utoronto.ca.
Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, ON, Canada. juris@ai.utoronto.ca.
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia. juris@ai.utoronto.ca.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Improving Analysis and Annotation of...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Improving Analysis and Annotation of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Improving Analysis and Annotation of...
questionsmedicales.fr › Techniques d'investigation › Procédures d'analyse sur micropuce › Analyse sur microréseau › Improving Analysis and Annotation of...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Annotation de séquence moléculaire › Improving Analysis and Annotation of...