Brain functional connectivity in patients with hyperthyroidism after anti-thyroid treatment.
Adult
Antithyroid Agents
/ therapeutic use
Brain
/ cytology
Brain Mapping
Carbimazole
/ therapeutic use
Cognition
/ drug effects
Cohort Studies
Executive Function
/ drug effects
Female
Humans
Hyperthyroidism
/ diagnosis
India
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
/ diagnostic imaging
Neuropsychological Tests
euthyroid
functional connectivity
hyperthyroidism
independent components
resting state networks
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
20
11
2021
received:
08
05
2021
accepted:
30
11
2021
pubmed:
15
12
2021
medline:
19
3
2022
entrez:
14
12
2021
Statut:
ppublish
Résumé
Thyroid disease is known to affect brain metabolism and cognitive function, although the recovery of thyroid-induced brain functional changes after treatment remains unclear. We aimed to investigate the alteration in brain functional connectivity and its correlation with neuropsychological variables in hyperthyroid patients before and after anti-thyroid treatment using a resting-state functional magnetic resonance imaging (rsfMRI) technique. This is a follow-up rsfMRI study of previous work that showed impaired brain functional connectivity in hyperthyroid patients compared to healthy controls. We included rsfMRI and neuropsychological data from 21 hyperthyroid patients out of an original cohort of 28 patients, before and after anti-thyroid treatment for 30 weeks. Functional connectivity analysis and neuropsychological scores were compared using paired t tests in patients at baseline and at follow-up. Patients showed an improvement in some of the memory (p < .05) and executive, visuospatial and motor (p < .001) functions after treatment, and also showed increased functional connectivity in the regions of the right fronto-parietal network, left fronto-parietal network, and default mode network (DMN) (p < .05). At follow-up, the functional connectivity of the right fronto-parietal network showed a significantly positive correlation with the recognition of objects memory score. The overall findings suggest that anti-thyroid treatment with carbimazole improves the functional connectivity within some of the resting state networks in the hyperthyroid patients, whereas the remaining networks still show impairment.
Substances chimiques
Antithyroid Agents
0
Carbimazole
8KQ660G60G
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13075Informations de copyright
© 2021 British Society for Neuroendocrinology.
Références
Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301-316.
Bauer M, Goetz T, Glenn T, Whybrow PC. The thyroid-brain interaction in thyroid disorders and mood disorders. J Neuroendocrinol. 2008;20(10):1101-1114.
Fahrenfort JJ, Wilterdink AM, van der Veen EA. Long-term residual complaints and psychosocial sequelae after remission of hyperthyroidism. Psychoneuroendocrinology. 2000;25(2):201-211.
Whybrow PC, Prange AJ Jr, Treadway CR. Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement. Arch Gen Psychiatry. 1969;20(1):48-63.
Yudiarto FL, Muliadi L, Moeljanto D, Hartono B. Neuropsychological findings in hyperthyroid patients. Acta Med Indones. 2006;38(1):6-10.
Vogel A, Elberling TV, Hørding M, Dock J, Rasmussen ÅK, Feldt-Rasmussen U, Perrild H, Waldemar G. Affective symptoms and cognitive functions in the acute phase of Graves’ thyrotoxicosis. Psychoneuroendocrinology. 2007;32(1):36-43. https://doi.org/10.1016/j.psyneuen.2006.09.012
Yuan L, Zhang Y, Luan D, et al. Reversible affective symptoms and attention executive control network impairment following thyroid function normalization in hyperthyroidism. Neuropsychiatr Dis Treat. 2019;153;305-312.
Villanueva I, Alva-Sanchez C, Pacheco-Rosado J. The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid Med Cell Longev. 2013;2013:1-15.
Zhang W, Liu X, Zhang Y, et al. Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: evidence from resting-state fMRI. Eur J Radiol. 2014;83(10):1907-1913.
Liu B, Ran Q, Liu D, Zhang S, Zhang D. Changes in resting-state cerebral activity in patients with hyperthyroidism: a short-term follow-up functional MR imaging study. Sci Rep. 2017;7(1):10627.
Liu BWL, Ran Q, Zhang S, Hu J, Gong M, Zhang D. Dysregulation within the salience network and default mode network in hyperthyroid patients: a follow-up resting-state functional MRI study. Brain Imaging Behav. 2020;14:30-41.
Li L, Zhi M, Hou Z, Zhang Y, Yue Y, Yuan Y. Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study. Oncotarget. 2017;8(4):6283-6294.
Göttlich M, Heldmann M, Göbel A, Dirk AL, Brabant G, Münte TF. Experimentally induced thyrotoxicosis leads to increased connectivity in temporal lobe structures: A resting state fMRI study. Psychoneuroendocrinology. 2015;56:100-109. http://dx.doi.org/10.1016/j.psyneuen.2015.03.009
Kumar M, Rana P, Modi S, et al. Aberrant intra and inter network resting state functional connectivity in thyrotoxicosis. J Neuroendocrinol. 2019;31(2):e12683.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. J Psychiatr Res. 1975;12(3):189-198.
Pershad DVS. Handbook of PGI Battery of Brain Dysfunction (PGI-BBD), 1st ed. National Psychological Corporation; 1990.
Jenkinson M, Bannister P, Brady M, Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. NeuroImage. 2002;17(2):825-841.
Smith SM. Fast robust automated brain extraction. Hum Brain Mapp. 2002;17(3):143-155.
Beckmann CF, DeLuca M, Devlin JT, Smith SM. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci. 2005;360(1457):1001-1013.
Beckmann CF, Mackay CE, Filippini N, Smith SM. Group comparison of resting-state fMRI data using multi-subject ICA and dual regression. NeuroImage. 2009;47:S148.
Filippini N, MacIntosh BJ, Hough MG, et al. Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci USA. 2009;106(17):7209-7214.
Storti SF, Formaggio E, Nordio R, et al. Automatic selection of resting-state networks with functional magnetic resonance imaging. Front Neurosci. 2013;7:72.
Damoiseaux JS, Beckmann CF, Arigita EJ, et al. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex. 2008;18(8):1856-1864.
Filippini N, Nickerson LD, Beckmann CF, et al. Age-related adaptations of brain function during a memory task are also present at rest. NeuroImage. 2012;59(4):3821-3828.
Sang L, Qin W, Liu Y, et al. Resting-state functional connectivity of the vermal and hemispheric subregions of the cerebellum with both the cerebral cortical networks and subcortical structures. NeuroImage. 2012;61(4):1213-1225.
Nichols TE, Holmes AP. Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp. 2002;15(1):1-25.
Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. NeuroImage. 2009;44(1):83-98.
Parks EL, Madden DJ. Brain connectivity and visual attention. Brain Connect. 2013;3(4):317-338.
Weiss AP, Ellis CB, Roffman JL, et al. Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigation. J Neurosci. 2009;29(36):11347-11359.
Zhu D, Chang J, Freeman S, et al. Changes of functional connectivity in the left frontoparietal network following aphasic stroke. Front Behav Neurosci. 2014;8:167.
Iidaka T, Sadato N, Yamada H, Yonekura Y. Functional asymmetry of human prefrontal cortex in verbal and non-verbal episodic memory as revealed by fMRI. Cognitive Brain Research. 2000;9(1):73-83. http://dx.doi.org/10.1016/s0926-6410(99)00047-6
Ostby Y, Tamnes CK, Fjell AM, Walhovd KB. Morphometry and connectivity of the fronto-parietal verbal working memory network in development. Neuropsychologia. 2011;49(14):3854-3862.
Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann NY Acad Sci. 2008;1124:1-38.
Sestieri C, Corbetta M, Romani GL, Shulman GL. Episodic memory retrieval, parietal cortex, and the default mode network: functional and topographic analyses. J Neurosci. 2011;31(12):4407-4420.