Cell-extracellular matrix dynamics.
cell migration
dynamics
extracellular matrix
focal adhesions
Journal
Physical biology
ISSN: 1478-3975
Titre abrégé: Phys Biol
Pays: England
ID NLM: 101197454
Informations de publication
Date de publication:
12 01 2022
12 01 2022
Historique:
received:
12
08
2021
accepted:
15
12
2021
pubmed:
16
12
2021
medline:
27
1
2022
entrez:
15
12
2021
Statut:
epublish
Résumé
The sites of interaction between a cell and its surrounding microenvironment serve as dynamic signaling hubs that regulate cellular adaptations during developmental processes, immune functions, wound healing, cell migration, cancer invasion and metastasis, as well as in many other disease states. For most cell types, these interactions are established by integrin receptors binding directly to extracellular matrix proteins, such as the numerous collagens or fibronectin. For the cell, these points of contact provide vital cues by sampling environmental conditions, both chemical and physical. The overall regulation of this dynamic interaction involves both extracellular and intracellular components and can be highly variable. In this review, we highlight recent advances and hypotheses about the mechanisms and regulation of cell-ECM interactions, from the molecular to the tissue level, with a particular focus on cell migration. We then explore how cancer cell invasion and metastasis are deeply rooted in altered regulation of this vital interaction.
Identifiants
pubmed: 34911051
doi: 10.1088/1478-3975/ac4390
pmc: PMC8855216
mid: NIHMS1772388
doi:
Substances chimiques
Integrins
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Intramural NIH HHS
ID : Z01 DE000524
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DE000718
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DE000719
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 DE999999
Pays : United States
Informations de copyright
Creative Commons Attribution license.
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