Expedited synthesis of mannose-6-phosphate containing oligosaccharides.

Mannose Mannosephosphates Oligosaccharides Polysaccharides Solid-Phase Synthesis Techniques

Journal

Carbohydrate research
ISSN: 1873-426X
Titre abrégé: Carbohydr Res
Pays: Netherlands
ID NLM: 0043535

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 29 11 2021
revised: 08 12 2021
accepted: 09 12 2021
pubmed: 19 12 2021
medline: 5 4 2022
entrez: 18 12 2021
Statut: ppublish

Résumé

Currently, the reaction toolbox for the functionalization of glycans assembled on solid-phase is quite limited. Automated (1 h) and manual (overnight) phosphorylation protocols that enable the solid-phase synthesis of oligosaccharides containing up to two mannose-6-phosphates are presented. Automated glycan assembly expedited access to substrates and facilitated the screening of experimental conditions.

Identifiants

DOI: 10.1016/j.carres.2021.108489 PMID: 34922155
pubmed: 34922155
pii: S0008-6215(21)00258-5
doi: 10.1016/j.carres.2021.108489
pii:
doi:

Substances chimiques

Mannosephosphates 0
Oligosaccharides 0
Polysaccharides 0
mannose-6-phosphate 3672-15-9
Mannose PHA4727WTP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108489

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Eric T Sletten (ET)

Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany.

José Danglad-Flores (J)

Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany.

Sabrina Leichnitz (S)

Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany.

A Abragam Joseph (A)

Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany.

Peter H Seeberger (PH)

Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany. Electronic address: peter.seeberger@mpikg.mpg.de.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Mannose › Expedited synthesis of mannose-6-phosphate...
questionsmedicales.fr › Glucides › Oses phosphates › Hexose phosphate › Mannose phosphate › Expedited synthesis of mannose-6-phosphate...
questionsmedicales.fr › Glucides › Polyosides › Oligosaccharides › Expedited synthesis of mannose-6-phosphate...
questionsmedicales.fr › Glucides › Polyosides › Expedited synthesis of mannose-6-phosphate...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Techniques de synthèse en phase solide › Expedited synthesis of mannose-6-phosphate...