Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
Animals
CD8-Positive T-Lymphocytes
/ immunology
Carbon Tetrachloride
/ administration & dosage
Cell Communication
/ immunology
Disease Models, Animal
Humans
Inducible T-Cell Co-Stimulator Ligand
/ metabolism
Inducible T-Cell Co-Stimulator Protein
/ genetics
Liver
/ cytology
Liver Failure, Acute
/ chemically induced
Liver Regeneration
/ immunology
Macrophages
/ immunology
Male
Mice
Mice, Knockout
Signal Transduction
/ immunology
acute liver injury
carbon tetrachloride poisoning
liver healing
liver inflammation
macrophage phenotype
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
09
2021
accepted:
08
11
2021
entrez:
20
12
2021
pubmed:
21
12
2021
medline:
15
2
2022
Statut:
epublish
Résumé
The liver capacity to recover from acute liver injury is a critical factor in the development of acute liver failure (ALF) caused by viral infections, ischemia/reperfusion or drug toxicity. Liver healing requires the switching of pro-inflammatory monocyte-derived macrophages(MoMFs) to a reparative phenotype. However, the mechanisms involved are still incompletely characterized. In this study we investigated the contribution of T-lymphocyte/macrophage interaction through the co-stimulatory molecule Inducible T-cell co-stimulator (ICOS; CD278) and its ligand (ICOSL; CD275) in modulating liver repair. The role of ICOS/ICOSL dyad was investigated during the recovery from acute liver damage induced by a single dose of carbon tetrachloride (CCl
Identifiants
pubmed: 34925367
doi: 10.3389/fimmu.2021.786680
pmc: PMC8678521
doi:
Substances chimiques
Icos protein, mouse
0
Icosl protein, mouse
0
Inducible T-Cell Co-Stimulator Ligand
0
Inducible T-Cell Co-Stimulator Protein
0
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
786680Informations de copyright
Copyright © 2021 Ramavath, Gadipudi, Provera, Gigliotti, Boggio, Bozzola, Albano, Dianzani and Sutti.
Déclaration de conflit d'intérêts
UD, EB, and LCG are listed as inventors on the patent PCT/IB2019/050154 “Novel anti-tumor therapeutic agents”. EB, UD, and LCG are founders of an University Spin-off (NOVAICOS). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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