Angicin, a novel bacteriocin of Streptococcus anginosus.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
received:
14
09
2021
accepted:
01
12
2021
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
1
2
2022
Statut:
epublish
Résumé
As a conserved defense mechanism, many bacteria produce antimicrobial peptides, called bacteriocins, which provide a colonization advantage in a multispecies environment. Here the first bacteriocin of Streptococcus anginosus, designated Angicin, is described. S. anginosus is commonly described as a commensal, however it also possesses a high pathogenic potential. Therefore, understanding factors contributing to its host colonization and persistence are important. A radial diffusion assay was used to identify S. anginosus BSU 1211 as a potent bacteriocin producer. By genetic mutagenesis the background of bacteriocin production and the bacteriocin gene itself were identified. Synthetic Angicin shows high activity against closely related streptococci, listeria and vancomycin resistant enterococci. It has a fast mechanism of action and causes a membrane disruption in target cells. Angicin, present in cell free supernatant, is insensitive to changes in temperature from - 70 to 90 °C and pH values from 2 to 10, suggesting that it represents an interesting compound for potential applications in food preservation or clinical settings.
Identifiants
pubmed: 34934110
doi: 10.1038/s41598-021-03797-5
pii: 10.1038/s41598-021-03797-5
pmc: PMC8692603
doi:
Substances chimiques
Bacterial Proteins
0
Bacteriocins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24377Informations de copyright
© 2021. The Author(s).
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