Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome.
Adult
Aged
Aged, 80 and over
Aortic Aneurysm, Thoracic
/ blood
Biomarkers
/ blood
Blood Vessel Prosthesis Implantation
/ adverse effects
Endovascular Procedures
/ adverse effects
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Complications
/ blood
Prognosis
Retrospective Studies
Risk Assessment
/ methods
Severity of Illness Index
Survival Rate
Zinc
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
received:
30
09
2021
accepted:
06
12
2021
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
1
2
2022
Statut:
epublish
Résumé
Thoracoabdominal aortic aneurysm (TAAA) repair is related to a relevant morbidity and in-hospital mortality rate. In this retrospective observational single-center study including serum zinc levels of 33 patients we investigated the relationship between zinc and patients' outcome following TAAA repair. Six patients died during the hospital stay (18%). These patients showed significantly decreased zinc levels before the intervention (zinc levels before intervention: 60.09 µg/dl [survivors] vs. 45.92 µg/dl [non-survivors]). The post-interventional intensive care SOFA-score (Sepsis-related organ failure assessment) (at day 2) as well as the SAPS (Simplified Acute Physiology Score) (at day 2) showed higher score points in case of low pre-interventional zinc levels. No significant correlation between patient comorbidities and zinc level before intervention, except for peripheral arterial disease (PAD), which was significantly correlated to reduced baseline zinc levels, was observed. Septic shock, pneumonia and urinary tract infections were not associated to reduced zinc levels preoperatively as well as during therapy. Patients with adverse outcome after TAAA repair showed reduced pre-interventional zinc levels. We speculate that decreased zinc levels before intervention may be related to a poorer outcome because of poorer physical status as well as negatively altered perioperative inflammatory response.
Identifiants
pubmed: 34934131
doi: 10.1038/s41598-021-03877-6
pii: 10.1038/s41598-021-03877-6
pmc: PMC8692510
doi:
Substances chimiques
Biomarkers
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24348Informations de copyright
© 2021. The Author(s).
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