TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer.
Biomarkers, Tumor
/ genetics
Cell Line, Tumor
Cell Movement
Dioxygenases
/ genetics
Endometrial Neoplasms
/ genetics
Epigenesis, Genetic
Epithelial-Mesenchymal Transition
Female
Forkhead Transcription Factors
/ genetics
Gene Expression Regulation, Neoplastic
Histones
/ metabolism
Humans
N-Acetylglucosaminyltransferases
/ genetics
Nuclear Proteins
/ genetics
Promoter Regions, Genetic
Transfection
Twist-Related Protein 1
/ genetics
Up-Regulation
Zinc Finger E-box-Binding Homeobox 1
/ genetics
FOXC1
O-GlcNAc transferase
TET proteins
TWIST1
ZEB1
endometrial cancer
invasion
migration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Dec 2021
08 Dec 2021
Historique:
received:
02
11
2021
revised:
03
12
2021
accepted:
03
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
3
2
2022
Statut:
epublish
Résumé
TET3 is a member of the TET (ten-eleven translocation) proteins family that catalyzes the conversion of the 5-methylcytosine into 5-hydroxymethylcytosine. TET proteins can also affect chromatin modifications and gene expression independently of their enzymatic activity via interactions with other proteins. O-GlcNAc transferase (OGT), the enzyme responsible for modification of proteins via binding of
Identifiants
pubmed: 34948036
pii: ijms222413239
doi: 10.3390/ijms222413239
pmc: PMC8708691
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
FOXC1 protein, human
0
Forkhead Transcription Factors
0
Histones
0
Nuclear Proteins
0
TWIST1 protein, human
0
Twist-Related Protein 1
0
ZEB1 protein, human
0
Zinc Finger E-box-Binding Homeobox 1
0
TET3 protein, human
EC 1.-
Dioxygenases
EC 1.13.11.-
N-Acetylglucosaminyltransferases
EC 2.4.1.-
OGT protein, human
EC 2.4.1.255
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Centre of Poland
ID : UMO-2015/19/N/NZ3/01311
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