Flagellin From
COVID19
Pseudomonas aeruginosa
SARS-CoV-2
TLR5
cystic fibrosis
infection
protease
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
05
2021
accepted:
05
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
7
1
2022
Statut:
epublish
Résumé
In the coronavirus disease 2019 (COVID-19) health crisis, one major challenge is to identify the susceptibility factors of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in order to adapt the recommendations for populations, as well as to reduce the risk of COVID-19 development in the most vulnerable people, especially patients with chronic respiratory diseases such as cystic fibrosis (CF). Airway epithelial cells (AECs) play a critical role in the modulation of both immune responses and COVID-19 severity. SARS-CoV-2 infects the airway through the receptor angiotensin-converting enzyme 2, and a host protease, transmembrane serine protease 2 (TMPRSS2), plays a major role in SARS-CoV-2 infectivity. Here, we show that
Identifiants
pubmed: 34950129
doi: 10.3389/fimmu.2021.714027
pmc: PMC8688244
doi:
Substances chimiques
Bacterial Proteins
0
Flagellin
12777-81-0
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
714027Informations de copyright
Copyright © 2021 Ruffin, Bigot, Calmel, Mercier, Givelet, Oliva, Pizzorno, Rosa-Calatrava, Corvol, Balloy, Terrier and Guillot.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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