Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.
Adult
Brain Injuries
/ etiology
COVID-19
/ complications
Cesarean Section
Female
Fetal Movement
Humans
Infant, Newborn
Infant, Premature
Infectious Disease Transmission, Vertical
Leukomalacia, Periventricular
/ etiology
Placenta
/ pathology
Pregnancy
Pregnancy Complications, Infectious
/ physiopathology
SARS-CoV-2
/ isolation & purification
COVID-19
MRI
SARS-CoV-2
brain injury
fetal movements
neurosonography
perinatal
placental
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
15 12 2021
15 12 2021
Historique:
received:
24
11
2021
revised:
07
12
2021
accepted:
10
12
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
7
1
2022
Statut:
epublish
Résumé
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
Identifiants
pubmed: 34960786
pii: v13122517
doi: 10.3390/v13122517
pmc: PMC8706116
pii:
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
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