Peroxide-Induced Damage to Plasminogen Molecules.

Fibrin Fibrinogen Fibrinolysin Fibrinolysis Oxidants Peroxides Plasminogen
antioxidant methionines electrophoresis hydrogen peroxide mass spectrometry oxidation oxidation sites plasminogen/plasmin

Journal

Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895

Informations de publication

Date de publication:
Nov 2021
Historique:
received: 19 05 2021
accepted: 17 07 2021
revised: 16 07 2021
entrez: 30 12 2021
pubmed: 31 12 2021
medline: 12 2 2022
Statut: ppublish

Résumé

Plasminogen is a zymogenic form of plasmin, an enzyme that plays a fundamental role in the dissolution of fibrin clots as well as in many other physiological processes. For the first time, by the method of gas chromatography-mass spectrometry, post-translational modifications in the primary structure of plasminogen treated with physiologically relevant amounts of hydrogen peroxide were identified. It was found that methionine and tryptophan residues located in different structural regions of plasminogen served as targets of the oxidant. Plasminogen oxidation caused a dose-dependent effect in decreasing the fibrinogenolytic activity of plasmin evidenced by the formation of fibrinogen degradation products. The possible antioxidant role of methionines in the oxidative modification of plasminogen is discussed.

Identifiants

DOI: 10.1134/S1607672921060053 PMID: 34966964
pubmed: 34966964
doi: 10.1134/S1607672921060053
pii: 10.1134/S1607672921060053
doi:

Substances chimiques

Oxidants 0
Peroxides 0
Fibrin 9001-31-4
Fibrinogen 9001-32-5
Plasminogen 9001-91-6
Fibrinolysin EC 3.4.21.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

419-423

Informations de copyright

© 2021. Pleiades Publishing, Ltd.

Références

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Auteurs

A D Vasilyeva (AD)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. alexandra.d.vasilyeva@gmail.com.

V S Ivanov (VS)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.

L V Yurina (LV)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.

M I Indeykina (MI)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
Moscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia.

A E Bugrova (AE)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.

A S Kononikhin (AS)

Talrose Institute for Energy Problems of Chemical Physics, Semenov Federal Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.

E N Nikolaev (EN)

Skolkovo Institute of Science and Technology, Skolkovo, Russia.

M A Rosenfeld (MA)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Fibrine › Peroxide-Induced Damage to Plasminogen Molecules.
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinogène › Peroxide-Induced Damage to Plasminogen Molecules.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Fibrinolysine › Peroxide-Induced Damage to Plasminogen Molecules.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Fibrinolyse › Peroxide-Induced Damage to Plasminogen Molecules.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Oxydants › Peroxide-Induced Damage to Plasminogen Molecules.
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxide-Induced Damage to Plasminogen Molecules.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Proenzymes › Plasminogène › Peroxide-Induced Damage to Plasminogen Molecules.